The effect of melaxen on the activity of caspases and the glutathione antioxidant system in toxic liver injury.

S S Popov, K K Shulgin, A N Pashkov, A A Agarkov

Open access · bronzeAbstract read

In one paragraph

Article in Acta naturae, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

S S PopovN.N. Burdenko Voronezh State Medical Academy, Ministry of Health of the Russian Federation, Studencheskaya Str. 10, Voronezh, Russia, 394036.

K K ShulginVoronezh State University, Ministry of Education and Science of the Russian Federation, Universitetskaya Str. 1, Voronezh, Russia, 394006.

A N PashkovN.N. Burdenko Voronezh State Medical Academy, Ministry of Health of the Russian Federation, Studencheskaya Str. 10, Voronezh, Russia, 394036.

A A AgarkovVoronezh State University, Ministry of Education and Science of the Russian Federation, Universitetskaya Str. 1, Voronezh, Russia, 394006.

Ministry of Health of the Russian Federation · RUVoronezh State Pedagogical University · RUVoronezh State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comparative study of the activity of caspase-1 and caspase-3, the glutathione antioxidant system and NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) and a study of DNA fragmentation in the blood serum of patients with chronic alcoholic hepatitis during basic treatment and combination therapy including melaxen have been carried out. It was found that the blood serum level of reduced glutathione, which decreases in pathology, increased more significantly in patients receiving melaxen as compared to the group of patients receiving the standard treatment. More significant changes in the activity of caspase-1 and caspase-3, glutathione reductase, glutathione peroxidase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase toward the control values were observed during the combination therapy. The correction in the melatonin level under the influence of melaxen apparently had a positive effect on the free-radical homeostasis in patients, which resulted in more pronounced changes in the investigated parameters towards the normal values as compared to the basic treatment. KEY WORD S chronic alcoholic hepatitis; glutathione peroxidase; glutathione reductase; reduced glutathione; glutathione-S-transferase; caspases; melaxen.

Indexed as

caspaseschronic alcoholic hepatitisglutathione peroxidaseglutathione reductaseglutathione-S-transferasemelaxenreduced glutathione

Identifiers

PMID25093118

PMCPMC4115233

OpenAlexW2961652318

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.