ArticleActa naturae2014
Structural Features of the Telomerase RNA Gene in the Naked Mole Rat Heterocephalus glaber.
Article in Acta naturae, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Epigenetic aging of the demographically non-aging naked mole-rat.Nature communications · 2022Article
- The use of non-traditional models in the study of cancer resistance-the case of the naked mole rat.Oncogene · 2020Review
- Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.GeroScience · 2020Article
- Unraveling the message: insights into comparative genomics of the naked mole-rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.Neurochemical research · 2016Article
- DNA methylation of genes of the main components of the telomerase complex in Danio rerio.Doklady. Biochemistry and biophysics · 2015Article
- Genome Stability Maintenance in Naked Mole-Rat.Acta naturaeArticle
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere length, an important feature of life span control, is dependent on the activity of telomerase (a key enzyme of the telomere-length-maintaining system). Telomerase RNA is a component of telomerase and, thus, is crucial for its activity. The structures of telomerase RNA genes and their promoter regions were compared for the long-living naked mole rat and different organisms. Two rare polymorphisms in Heterocephalus glaber telomerase RNA (hgTER) were identified: A→G in the first loop of pseudoknot P2b-p3 (an equivalent of 111nt in hTR) and G→A in the scaRNA domain CR7-p8b (an equivalent of 421nt in hTR). Analysis of TER promoter regions allowed us to identify two new transcription factor binding sites. The first one is the ETS family site, which was found to be a conserved element for all the analyzed TER promoters. The second site is unique for the promoter region of TER of the naked mole rat and is a binding site for the SOX17 transcription factor. The absence of one Sp1 site in the TER promoter region of the naked small rat is an additional specific feature of the promoter area of hgTER. Such variation in the hgTER transcription regulation region and hgTER itself could provide increased telomerase activity in stem cells and an extended lifespan to H. glaber.
Indexed as
Identifiers
25093110PMC4115225W2120674924What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.