ArticleInfection and immunity2014
Thorax injury lowers resistance to infection in Drosophila melanogaster.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
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- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- How frequently are insects wounded in the wild? A case study usingRoyal Society open science · 2024Article
- Effects of an entomopathogenic fungus on the reproductive potential ofEcology and evolution · 2024Article
- Impact of Chronic Infection on Resistance and Tolerance to Secondary Infection in Drosophila melanogaster.Infection and immunity · 2023Article
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- The Drosophila Baramicin polypeptide gene protects against fungal infection.PLoS pathogens · 2021Article
- Host-pathogen immune feedbacks can explain widely divergent outcomes from similar infections.Proceedings. Biological sciences · 2021Article
- Dense time-course gene expression profiling of the Drosophila melanogaster innate immune response.BMC genomics · 2021Article
- Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.Developmental cell · 2019Article
- Viral infection causes sex-specific changes in fruit fly social aggregation behaviour.Biology letters · 2019Article
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- Immune priming and clearance of orally acquired RNA viruses in Drosophila.Nature microbiology · 2018Article
- Oral Bacterial Infection and Shedding in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2018Article
- Evaluation of Providencia rettgeri pathogenicity against laboratory Mediterranean fruit fly strain (Ceratitis capitata).PloS one · 2018Article
- Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA.Scientific reports · 2017Article
- Stochastic variation in the initial phase of bacterial infection predicts the probability of survival ineLife · 2017Article
- Sex-Specific Routes To Immune Senescence In Drosophila melanogaster.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The route of infection can profoundly affect both the progression and outcome of disease. We investigated differences in Drosophila melanogaster defense against infection after bacterial inoculation into two sites--the abdomen and the thorax. Thorax inoculation results in increased bacterial proliferation and causes high mortality within the first few days of infection. In contrast, abdomen inoculation results in minimal mortality and lower bacterial loads than thorax inoculation. Inoculation into either site causes systemic infection. Differences in mortality and bacterial load are due to injury of the thorax and can be recapitulated by abdominal inoculation coupled with aseptic wounding of the thorax. This altered resistance appears to be independent of classical immune pathways and opens new avenues of research on the role of injury during defense against infection.
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Registered trials
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