ArticleThe American journal of tropical medicine and hygiene2014
Inadequacy of IgM antibody tests for diagnosis of Rocky Mountain Spotted Fever.
Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Predictors of Fatal Outcomes among Pediatric Patients Hospitalized for Rocky Mountain Spotted Fever, Sonora, Mexico, 2004-2024Emerging infectious diseases · 2026Article
- A Mini-Review of Diagnostic Methods for the Antigen and Antibody Detection of Rocky Mountain and Brazilian Spotted Fever.Biomedicines · 2024Review
- Touching Base with Some Mediterranean Diseases of Interest from Paradigmatic Cases at the "Magna Graecia" University Unit of Infectious Diseases: A Didascalic Review.Diagnostics (Basel, Switzerland) · 2023Review
- False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011-2021.Pathogens (Basel, Switzerland) · 2023Article
- Antibody Prevalence and Risk Factors Associated withPathogens (Basel, Switzerland) · 2022Article
- A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes.PLoS neglected tropical diseases · 2022Review
- Case Report: Rocky Mountain Spotted Fever with Adrenalectomy and a Hard-to-Find Tick.The American journal of case reports · 2022Article
- An Update on the Laboratory Diagnosis ofPathogens (Basel, Switzerland) · 2021Review
- Spotted fever diagnosis: Experience from a South Indian center.Pathogens and global health · 2021Article
- Assessing human exposure to spotted fever and typhus group rickettsiae in Ontario, Canada (2013-2018): a retrospective, cross-sectional study.BMC infectious diseases · 2020Article
- Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia.Emerging infectious diseases · 2020Article
- Brain Death Secondary to Rocky Mountain Spotted Fever Encephalitis.Case reports in critical care · 2020Article
- Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii.Journal of veterinary internal medicine · 2020Article
- Diagnosis of spotted fever groupEpidemiology and infection · 2019Review
- Diagnostic Methods Used to Classify Confirmed and Probable Cases of Spotted Fever Rickettsioses - United States, 2010-2015.MMWR. Morbidity and mortality weekly report · 2019Article
- The Rickettsioses: A Practical Update.Infectious disease clinics of North America · 2019Review
- Article
- State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus.Current opinion in infectious diseases · 2016Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among 13 suspected Rocky Mountain spotted fever (RMSF) cases identified through an enhanced surveillance program in Tennessee, antibodies to Rickettsia rickettsii were detected in 10 (77%) patients using a standard indirect immunofluorescent antibody (IFA) assay. Immunoglobulin M (IgM) antibodies were observed for 6 of 13 patients (46%) without a corresponding development of IgG, and for 3 of 10 patients (30%) at least 1 year post-onset. However, recent infection with a spotted fever group rickettsiae could not be confirmed for any patient, based on a lack of rising antibody titers in properly timed acute and convalescent serologic specimens, and negative findings by polymerase chain reaction testing. Case definitions used in national surveillance programs lack specificity and may capture cases that do not represent current rickettsial infections. Use of IgM antibodies should be reconsidered as a basis for diagnosis and public health reporting of RMSF and other spotted fever group rickettsiae in the United States.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.