ArticleAntimicrobial agents and chemotherapy2014
The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
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- Bacteriophage Therapy to Control Bovine Mastitis: A Review.Antibiotics (Basel, Switzerland) · 2023Review
- Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race.International journal of molecular sciences · 2023Review
- RecT Affects Prophage Lifestyle and Host Core Cellular Processes in Pseudomonas aeruginosa.Applied and environmental microbiology · 2022Article
- Multi-species host range of staphylococcal phages isolated from wastewater.Nature communications · 2021Article
- Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.Antibiotics (Basel, Switzerland) · 2019Article
- Beer-spoilage characteristics ofFood science & nutrition · 2019Article
- Bacterial 'Grounded' Prophages: Hotspots for Genetic Renovation and Innovation.Frontiers in genetics · 2019Article
- Antimicrobial Resistance among Staphylococci of Animal Origin.Microbiology spectrum · 2018Review
- New Macrolide-Lincosamide-Streptogramin B Resistance GeneAntimicrobial agents and chemotherapy · 2017Article
- Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.Antibiotics (Basel, Switzerland) · 2017Review
- Phages rarely encode antibiotic resistance genes: a cautionary tale for virome analyses.The ISME journal · 2017Article
- A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.Antimicrobial agents and chemotherapy · 2017Article
- New shuttle vector-based expression system to generate polyhistidine-tagged fusion proteins in Staphylococcus aureus and Escherichia coli.Applied and environmental microbiology · 2015Article
- The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A novel erythromycin ribosome methylase gene, erm(44), that confers resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics was identified by whole-genome sequencing of the chromosome of Staphylococcus xylosus isolated from bovine mastitis milk. The erm(44) gene is preceded by a regulatory sequence that encodes two leader peptides responsible for the inducible expression of the methylase gene, as demonstrated by cloning in Staphylococcus aureus. The erm(44) gene is located on a 53-kb putative prophage designated ΦJW4341-pro. The 56 predicted open reading frames of ΦJW4341-pro are structurally organized into the five functional modules found in members of the family Siphoviridae. ΦJW4341-pro is site-specifically integrated into the S. xylosus chromosome, where it is flanked by two perfect 19-bp direct repeats, and exhibits the ability to circularize. The presence of erm(44) in three additional S. xylosus strains suggests that this putative prophage has the potential to disseminate MLSB resistance.
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