Evidence map›Paper›PMID 25092704›Full record

ArticleAntimicrobial agents and chemotherapy2014

Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.

Manuela Donalisio, Elisabetta Ranucci, Valeria Cagno, Andrea Civra, Amedea Manfredi, Roberta Cavalli, Paolo Ferruti, David Lembo

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manuela DonalisioDipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
Elisabetta RanucciDipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
Valeria CagnoDipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
Andrea CivraDipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
Amedea ManfrediDipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
Roberta CavalliDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Turin, Italy.
Paolo FerrutiDipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
David LemboDipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy david.lembo@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity.

Indexed as

AgmatineAntiviral AgentsCytomegalovirusHumansPolyaminesRotavirusSimplexvirusVesiculovirusAgmatineAntiviral AgentsPoly(amidoamine)Polyamines

Identifiers

PMID25092704
PMCPMC4187951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.