ArticleVaccine2014
Development of serum antibodies during early infancy in rhesus macaques: implications for humoral immune responses to vaccination at birth.
Article in Vaccine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Quantitative protein analysis and glycan profiling of umbilical cord plasma and corresponding maternal plasma samples.Scientific reports · 2026Article
- Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024Review
- Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids.Infection and immunity · 2022Article
- Review
- Bile acid transporter-mediated oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum.Science translational medicine · 2020Article
- Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models.Disease models & mechanisms · 2020Review
- Article
- Limited Neonatal Carbohydrate-Specific Antibody Repertoire Consecutive to Partial Prenatal Transfer of Maternal Antibodies.Frontiers in immunology · 2020Article
- Maternal antibodies against tetanus toxoid do not inhibit potency of antibody responses to autologous antigen in newborn rhesus monkeys.Journal of medical primatology · 2018Article
- TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.JCI insight · 2017Article
- Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination.Clinical and vaccine immunology : CVI · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA better understanding of immune responses in human infants could lead to more effective immunization and vaccination strategies in early life.
methodsSince antibodies are key components of protective vaccine responses, we examined developmental changes in serum levels of immunoglobulins (IgG, IgA, IgM) in infant rhesus macaques from birth through 6 months of age.
resultsAs in human infants, macaques are born with high levels of IgG in sera, with rapid increases in serum IgM, yet very slow increases in levels of IgA from birth. We also examined levels of anti-tetanus antibodies in infants born to vaccinated dams to distinguish and track maternal and infant antibodies. These data suggest essentially all serum IgG in newborn infants is derived from the dams, which gradually wanes over a few weeks. In contrast, levels of IgM and IgA appear to all be infant-derived, as evidenced by their low to undetectable levels at birth. In addition, abnormally high levels of serum IgM and IgA were detected in a few infants, which correlated with specific, yet clinically silent disease processes.
conclusionsOur data indicate that newborn macaques have competent immune systems, and are able to produce their own antibodies in response to exposure to environmental antigens immediately upon birth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.