ArticleClinical journal of the American Society of Nephrology : CJASN2014
Distinguishing characteristics of idiopathic calcium oxalate kidney stone formers with low amounts of Randall's plaque.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement.Journal of nephrology · 2016Guideline
- Short-Term Tolvaptan Increases Water Intake and Effectively Decreases Urinary Calcium Oxalate, Calcium Phosphate and Uric Acid Supersaturations.The Journal of urology · 2016Trial
- Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review).International journal of molecular medicine · 2026Review
- Validation of a Renal Papillary Grading System: Comparison of Patients Forming Calcium Oxalate and Apatite Stones.Journal of endourology · 2026Article
- Phenotyping of Idiopathic Calcium Oxalate Stone Formers Reveals Risk Factors for Papillary Lesions and Chronic Renal Function.Journal of endourology · 2026Article
- FABP3 deficiency exacerbates renal Randall plaque formation: insights from single-cell RNA transcriptomic analysis.Molecular and cellular biochemistry · 2026Article
- Cefazolin shifts the kidney microbiota to promote a lithogenic environment.Nature communications · 2024Article
- Identification of TIMPs signatures in Randall plaque from single-cell RNA sequencing (scRNA-Seq) analysis.Functional & integrative genomics · 2024Article
- Increased renal uptake and urine excretion of oxidized LDL is possibly associated with formation of large calcium oxalate nephrolithiasis: a preliminary study.World journal of urology · 2023Article
- Update on the Effect of the Urinary Microbiome on Urolithiasis.Diagnostics (Basel, Switzerland) · 2023Review
- Breaking the Cycle of Recurrent Calcium Stone Disease.Advances in kidney disease and health · 2023Review
- The renal pelvis urobiome in the unilateral kidney stone patients revealed by 2bRAD-M.Journal of translational medicine · 2022Article
- The pediatric urobiome in genitourinary conditions: a narrative review.Pediatric nephrology (Berlin, Germany) · 2022Review
- Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis.Journal of endourology · 2022Article
- The Microbiome and Urolithiasis: Current Advancements and Future Challenges.Current urology reports · 2022Review
- Three-channel ion chromatograph for improved metabolic evaluation of urolithiasis.BMC urology · 2021Article
- Risk of UTI in kidney stone formers: a matched-cohort study over a median follow-up of 19 years.World journal of urology · 2021Article
- Endoscopic Papillary Abnormalities and Stone Recognition (EPSR) during Flexible Ureteroscopy: A Comprehensive Review.Journal of clinical medicine · 2021Review
- Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers.BMC nephrology · 2021Article
- Relationship of endoscopic lesions of the renal papilla with type of renal stone and 24 h urine analysis.BMC urology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOvergrowth of calcium oxalate on Randall's plaque is a mechanism of stone formation among idiopathic calcium oxalate stone-formers (ICSFs). It is less clear how stones form when there is little or no plaque. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants were a consecutive cohort of ICSFs who underwent percutaneous nephroscopic papillary mapping in the kidney or kidneys containing symptomatic stones and a papillary tip biopsy from a representative calyx during a stone removal procedure between 2009 and 2013. The distribution of Randall's plaque coverage was analyzed and used to divide ICSFs into those with a high (≥5%; mean, 10.5%; n=10) versus low (<5%; mean, 1.5%; n=32) amount of plaque coverage per papilla. Demographic and laboratory features were compared between these two groups.
resultsLow-plaque stone formers tended to be obese (50% versus 10%; P=0.03) and have a history of urinary tract infection (34% versus 0%; P=0.04). They were less likely to have multiple prior stone events (22% versus 80%; P=0.002) and had a lower mean 24-hour urine calcium excretion (187±86 mg versus 291±99 mg; P<0.01). Morphologically, stones from patients with low amounts of plaque lacked a calcium phosphate core by microcomputed tomography. Papillary biopsies from low plaque stone-formers revealed less interstitial and basement membrane punctate crystallization.
conclusionsThese findings suggest that other pathways independent of Randall's plaque may contribute to stone pathogenesis among a subgroup of ICSFs who harbor low amounts of plaque.
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