ArticleMolecular genetics and genomics : MGG2014
Mitochondrial DNA haplogroup D4b is a protective factor for ischemic stroke in Chinese Han population.
Article in Molecular genetics and genomics : MGG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Association Study Between Genetic Variation in Whole Mitochondrial Genome and Ischemic Stroke.Journal of molecular neuroscience : MN · 2021Article
- Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population.Cells · 2020Article
- Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations.Frontiers in molecular biosciences · 2019Review
- Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke.Scientific reports · 2015Article
- Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.Neuroscience letters · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Mitochondrial DNA (mtDNA) haplogroups affect the assembly and stability of the mitochondrial respiratory chain, which is potentially related to susceptibility to ischemic stroke (IS). However, the role of mtDNA in IS has not been comprehensively studied. The purpose of this study was to explore whether mtDNA polymorphisms and haplogroups are involved in the etiology of IS in the Chinese Han population. We recruited 200 patients with IS and 200 matched controls and genotyped them for 18 mtDNA single nucleotide polymorphisms defining the major Eastern Asian haplogroups by SNaPshot minisequencing. We also sequenced the hypervariable segment I (HVS-I), position 16051-16400. The prevalence of haplogroup D4b was significantly lower in IS patients than in healthy controls (0 and 8 %, respectively, corrected P = 2 × 10(-5), odds ratio = 0.028, 95 % confidence interval = 0.002-0.468).The positive association between haplogroup D4b and IS may be related to the protective effect of haplogroup D4b against oxidative damage, which decreases the risk of IS. Our study provides the first evidence that haplogroup D4b is a potential genetic protective factor for IS in the Chinese Han population.
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