ArticleProceedings of the National Academy of Sciences of the United States of America2014
Synthesis and scavenging role of furan fatty acids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in obesity.Science advances · 2026Article
- The Furan Fatty Acids 11M5 and 11D5 Can Act as Activators of Human Peroxisome Proliferator-Activated Receptor Gamma.Molecular nutrition & food research · 2025Article
- The emerging significance of furan fatty acids in food, nutrition, and potential therapeutic use.Food chemistry · 2025Review
- Effect of SAM-Dependent Methyltransferases fromJournal of microbiology and biotechnology · 2025Article
- Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis.RSC chemical biology · 2024Article
- Lipid droplets inFrontiers in plant science · 2024Article
- Enrichment and structural assignment of geometric isomers of unsaturated furan fatty acids.Analytical and bioanalytical chemistry · 2023Article
- Investigation on Metabolites in Structural Diversity from the Deep-Sea Sediment-Derived BacteriumMarine drugs · 2022Article
- Chlamydomonas as a model for reactive oxygen species signaling and thiol redox regulation in the green lineage.Plant physiology · 2021Review
- Unified Approach to Furan Natural Products via Phosphine-Palladium Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
- Light Response ofJournal of bacteriology · 2020Article
- Solving a furan fatty acid biosynthesis puzzle.The Journal of biological chemistry · 2020Article
- A bacterial biosynthetic pathway for methylated furan fatty acids.The Journal of biological chemistry · 2020Article
- Adaptation to Photooxidative Stress: Common and Special Strategies of the AlphaproteobacteriaMicroorganisms · 2020Article
- Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.JAMA network open · 2019Article
- Shedding light on a Group IV (ECF11) alternative σ factor.Molecular microbiology · 2019Review
- Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils.Biomolecules · 2018Article
- A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data.Frontiers in genetics · 2018Article
- Article
- Antimicrobial photodynamic activity and cytocompatibility of AuInternational journal of nanomedicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Fatty acids play important functional and protective roles in living systems. This paper reports on the synthesis of a previously unidentified 19 carbon furan-containing fatty acid, 10,13-epoxy-11-methyl-octadecadienoate (9-(3-methyl-5-pentylfuran-2-yl)nonanoic acid) (19Fu-FA), in phospholipids from Rhodobacter sphaeroides. We show that 19Fu-FA accumulation is increased in cells containing mutations that increase the transcriptional response of this bacterium to singlet oxygen ((1)O2), a reactive oxygen species generated by energy transfer from one or more light-excited donors to molecular oxygen. We identify a previously undescribed class of S-adenosylmethionine-dependent methylases that convert a phospholipid 18 carbon cis unsaturated fatty acyl chain to a 19 carbon methylated trans unsaturated fatty acyl chain (19M-UFA). We also identify genes required for the O2-dependent conversion of this 19M-UFA to 19Fu-FA. Finally, we show that the presence of (1)O2 leads to turnover of 19Fu-Fa in vivo. We propose that furan-containing fatty acids like 19Fu-FA can act as a membrane-bound scavenger of (1)O2, which is naturally produced by integral membrane enzymes of the R. sphaeroides photosynthetic apparatus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.