ArticleProceedings of the National Academy of Sciences of the United States of America2014
Multimonth controlled small molecule release from biodegradable thin films.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Nano-layered tendon patch to orchestrate timely interactions between tendon stem/progenitor cells and macrophages.Biomaterials · 2027Article
- Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells.Biomaterials · 2023Article
- Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications.Pharmaceutics · 2022Review
- Targeted treatment for osteoarthritis: drugs and delivery system.Drug delivery · 2021Review
- Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications.ACS applied materials & interfaces · 2021Article
- Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy.Pharmaceutics · 2020Article
- Film interface for drug testing for delivery to cells in culture and in the brain.Acta biomaterialia · 2019Article
- Article
- Article
- Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Core/shell nanoassembly of amphiphilic naproxen-polyethylene glycol: synthesis, characterisation and evaluation as drug delivery system.IET nanobiotechnology · 2018Article
- Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues.Theranostics · 2018Article
- Binding Mechanism of the Model Charged Dye Carboxyfluorescein to Hyaluronan/Polylysine Multilayers.ACS applied materials & interfaces · 2017Article
- Macrophages with cellular backpacks for targeted drug delivery to the brain.Biomaterials · 2017Article
- Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI.International journal of environmental research and public health · 2017Article
- Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels.Journal of the American Chemical Society · 2017Article
- Heparin-based hydrogels with tunable sulfation & degradation for anti-inflammatory small molecule delivery.Biomaterials science · 2016Article
- Assembly and Immunological Processing of Polyelectrolyte Multilayers Composed of Antigens and Adjuvants.ACS applied materials & interfaces · 2016Article
- Biosynthetic Polymers as Functional Materials.Macromolecules · 2016Review
- Multifunctional Self-Assembled Films for Rapid Hemostat and Sustained Anti-infective Delivery.ACS biomaterials science & engineering · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity to vital organs typically caused by systemic administration and decreasing the need for medical intervention because of its long-lasting release. Also important is the ability to achieve high drug loadings in thin film coatings to allow incorporation of significant drug amounts on implant surfaces. Here we report a sustained release formulation for small molecules based on a soluble charged polymer-drug conjugate that is immobilized into nanoscale, conformal, layer-by-layer assembled films applicable to a variety of substrate surfaces. We measured a highly predictable sustained drug release from a polymer thin film coating of 0.5-2.7 μm that continued for more than 14 mo with physiologically relevant drug concentrations, providing an important drug delivery advance. We demonstrated this effect with a potent small molecule nonsteroidal anti-inflammatory drug, diclofenac, because this drug can be used to address chronic pain, osteoarthritis, and a range of other critical medical issues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.