Evidence map›Paper›PMID 25092112›Full record

ArticleProteomics2014

A standardized framing for reporting protein identifications in mzIdentML 1.2.

Sean L Seymour, Terry Farrah, Pierre-Alain Binz, Robert J Chalkley, John S Cottrell, Brian C Searle, David L Tabb, Juan Antonio Vizcaíno, Gorka Prieto, Julian Uszkoreit and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Proteomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Review
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  10. The SEQUEST family tree.Journal of the American Society for Mass Spectrometry · 2015
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 5 countries.

Sean L SeymourAB SCIEX, Redwood City, CA, USA.
Terry Farrah
Pierre-Alain Binz
Robert J Chalkley
John S Cottrell
Brian C Searle
David L Tabb
Juan Antonio Vizcaíno
Gorka Prieto
Julian Uszkoreit
Martin Eisenacher
Salvador Martínez-Bartolomé
Fawaz Ghali
Andrew R Jones
Ruhr University Bochum · DEUniversity of Liverpool · GBCañada College · USCentro Nacional de Biotecnología · ESEuropean Bioinformatics Institute · GBInstitute for Systems Biology · USProteome Sciences (United Kingdom) · GBSIB Swiss Institute of Bioinformatics · CHUniversity of California, San Francisco · USUniversity of the Basque Country · ESVanderbilt University · USWellcome Centre for Cell-Matrix Research · GB

Funding

UniProt: A Centralized Protein Sequence and Function ResourceU41HG006104 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI APWEILER, ROLF · 2010 to 2014
$23.5M
Bio-Organic Biomedical Mass Spectromy ResourceP41GM103481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURLINGAME, ALMA L · 2012 to 2015
$6.4M
Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
Complete Human Peptide- and MRM-AtlasRC2HG005805 · NHGRI · INSTITUTE FOR SYSTEMS BIOLOGY · PI HOOD, LEROY E, MORITZ, ROBERT L · 2009 to 2010
$4.6M
Biotechnology and Biological Sciences Research Council BB/I000909/1Biotechnology and Biological Sciences Research Council BB/I00095X/1Biotechnology and Biological Sciences Research Council BB/K004123/1Biotechnology and Biological Sciences Research Council BB/K01997X/1NHGRI NIH HHS 1RC2-HG005805-01NHGRI NIH HHS 1 U41 HG006104-01NHGRI NIH HHS RC2 HG005805NHGRI NIH HHS U41 HG006104NIGMS NIH HHS 8P41GM103481NIGMS NIH HHS P41 GM103481NIGMS NIH HHS R01 GM087221Wellcome TrustWellcome Trust WT085949MAWellcome Trust WT101477MA
6 · The paper itself

Abstract

Inferring which protein species have been detected in bottom-up proteomics experiments has been a challenging problem for which solutions have been maturing over the past decade. While many inference approaches now function well in isolation, comparing and reconciling the results generated across different tools remains difficult. It presently stands as one of the greatest barriers in collaborative efforts such as the Human Proteome Project and public repositories such as the PRoteomics IDEntifications (PRIDE) database. Here we present a framework for reporting protein identifications that seeks to improve capabilities for comparing results generated by different inference tools. This framework standardizes the terminology for describing protein identification results, associated with the HUPO-Proteomics Standards Initiative (PSI) mzIdentML standard, while still allowing for differing methodologies to reach that final state. It is proposed that developers of software for reporting identification results will adopt this terminology in their outputs. While the new terminology does not require any changes to the core mzIdentML model, it represents a significant change in practice, and, as such, the rules will be released via a new version of the mzIdentML specification (version 1.2) so that consumers of files are able to determine whether the new guidelines have been adopted by export software.

Indexed as

Databases, ProteinHumansMass SpectrometryProteinsProteomicsSoftwareProteinsBioinformaticsData standardsProtein identificationProteomics Standards InitiativeSoftwareXML

Identifiers

PMID25092112
PMCPMC4384534
OpenAlexW1998425197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.