ArticleJournal of bacteriology2014
Spermidine biosynthesis and transport modulate pneumococcal autolysis.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- PotD contributes to Streptococcus suis-induced blood-brain barrier disruption by regulating arcA transcription.Veterinary research · 2025Article
- Research progress on the microbial metabolism and transport of polyamines and their roles in animal gut homeostasis.Journal of animal science and biotechnology · 2025Review
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- Characterization of an Arginine Decarboxylase fromBiomolecules · 2024Article
- Polyamines: Key Players in Immunometabolism and Immune Regulation.Journal of cellular immunology · 2024Article
- A bacterial spermidine biosynthetic pathway via carboxyaminopropylagmatine.Science advances · 2023Article
- ComparativeFrontiers in neuroscience · 2023Article
- Growth ofJournal of oral microbiology · 2023Article
- A bacterial pan-genome makes gene essentiality strain-dependent and evolvable.Nature microbiology · 2022Article
- Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity.Medical sciences (Basel, Switzerland) · 2022Review
- A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism inInternational journal of molecular sciences · 2022Article
- Investigation of the polyamine biosynthetic and transport capability ofMicrobiology (Reading, England) · 2021Article
- The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae.Pneumonia (Nathan Qld.) · 2021Review
- SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis inFrontiers in microbiology · 2020Article
- Article
- Putrescine biosynthesis and export genes are essential for normal growth of avian pathogenic Escherichia coli.BMC microbiology · 2018Article
- Polyamine function in archaea and bacteria.The Journal of biological chemistry · 2018Review
- Spermidine promotesThe Journal of biological chemistry · 2017Article
- Gamma-Glutamylpolyamine Synthetase GlnA3 Is Involved in the First Step of Polyamine Degradation Pathway inFrontiers in microbiology · 2017Article
- Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamines are small cationic molecules that have far-reaching roles in biology. In the case of pathogenic bacteria, these functions include those central to their pathogenesis. Streptococcus pneumoniae is a major bacterial pathogen, causing a diverse range of diseases that account for significant morbidity and mortality worldwide. In this work, we characterize the polyamine biosynthetic pathway of S. pneumoniae, demonstrating that this organism produces spermidine from arginine. The synthesis of spermidine was found to be nonessential for growth in a polyamine-free chemically defined medium. However, mutant strains lacking the ability to synthesize or transport spermidine displayed a significant delay in the onset of autolysis. We provide evidence for a model in which spermidine modulates the activity of the major autolysin LytA in the pneumococcal cell wall compartment via interactions with negatively charged molecules, such as teichoic acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.