Evidence map›Paper›PMID 25091949›Full record

ArticleThe British journal of ophthalmology2014

Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration.

Celine Saade, Bhaskar Ganti, Michael Marmor, K Bailey Freund, R Theodore Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Simultaneous GA and CNV/MNV: incidence, characteristics, and treatments.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  4. Observational
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Celine SaadeDepartment of Ophthalmology, New York University School of Medicine, New York, New York, USA.
Bhaskar GantiDepartment of Ophthalmology, New York University School of Medicine, New York, New York, USA.
Michael MarmorDepartment of Population Health, New York University School of Medicine, New York, New York, USA Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA Department of Medicine, New York University School of Medicine, New York, New York, USA.
K Bailey FreundDepartment of Ophthalmology, New York University School of Medicine, New York, New York, USA Department of Ophthalmology, Columbia University, New York, New York, USA Vitreous Retina Macula Consultants of New York, New York, New York, USA LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA.
R Theodore SmithDepartment of Ophthalmology, New York University School of Medicine, New York, New York, USA.
New York University · US

Funding

Validated Autofluorescence in Age-Related Macular DegenerationR01EY015520 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, ROLAND THEODORE · 2005 to 2018
$6.0M
NEI NIH HHS R01 EY015520
6 · The paper itself

Abstract

aimTo investigate the risk characteristics of the combined geographic atrophy (GA) and choroidal neovascularisation (CNV) phenotype of age-related macular degeneration (AMD) compared to GA or CNV.

methodsPatients with advanced AMD were identified and divided into three groups using multimodal imaging: patients with GA in at least one eye, patients with CNV in at least one eye, and patients with simultaneous GA and CNV in at least one eye. Epidemiologic and clinical factors were gathered from patient questionnaires. Genotypes for age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) were determined.

results42 patients with GA or CNV, and 16 patients with combined GA/CNV were identified. Patients with the combined phenotype were older (86.4 vs 81.8 years, p=0.049), and had a higher prevalence of advanced AMD in the fellow eye (81.3% vs 31.0%, p<0.001). CFH and ARMS2 risk alleles were not associated with the combined phenotype.

conclusionsThe combined GA/CNV phenotype has similar epidemiologic, clinical, and genetic features as GA and CNV, but occurs at an older age and is more associated with advanced AMD in the fellow eye, suggesting that all these phenotypes are part of the same spectrum of disease and that the combined phenotype represents an even more advanced form of AMD than either GA or CNV.

Indexed as

AgedAged, 80 and overAllelesChoroidal NeovascularizationColoring AgentsComplement Factor HFemaleFluorescein AngiographyGenotypeGeographic AtrophyHumansIndocyanine GreenMacular DegenerationMaleMiddle AgedPhenotypeARMS2 protein, humanCFH protein, humanColoring AgentsComplement Factor HIndocyanine GreenProteinsMaculaNeovascularisation

Identifiers

PMID25091949
PMCPMC4233165
OpenAlexW1542971260

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.