ArticleSingapore medical journal2014
Inappropriate use of proton pump inhibitors in a local setting.
Article in Singapore medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Prevalence of polypharmacy: a cross-sectional study in Singapore public healthcare institutions.Singapore medical journal · 2026Article
- Deprescribing proton pump inhibitors in long-term care: Outcomes of a pharmacist-led initiative.Exploratory research in clinical and social pharmacy · 2026Article
- Predictive Factors Associated with Inappropriate Intravenous Proton Pump Inhibitors Use in Hospitalized Patients: A Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Pattern of Prescribing Proton Pump Inhibitors: Evaluating Appropriateness and Factors Contributing to Their Adverse Effect Reaction Risk.Journal of clinical medicine · 2024Article
- Article
- The Use of Proton Pump Inhibitors in Patients with Liver Cirrhosis: Real Life Experience.Journal of clinical medicine · 2024Article
- Physicians' perceptions and awareness of adverse effects of proton pump inhibitors and impact on prescribing patterns.Frontiers in pharmacology · 2024Article
- Assessment of the appropriateness of stress ulcer prophylaxis use and its determinants among admitted surgical patients at Debre Berhan University Hakim Gizaw Hospital, Ethiopia. A hospital-based cross-sectional study.Frontiers in medicine · 2024Article
- Proton Pump Inhibitors and Risk of Chronic Kidney Disease: Evidence from Observational Studies.Journal of clinical medicine · 2023Article
- Dose-Dependent Proton Pump Inhibitor Exposure and Risk of Type 2 Diabetes: A Nationwide Nested Case-Control Study.International journal of environmental research and public health · 2022Article
- Assessment of Awareness and Knowledge of Proton Pump Inhibitors Among the General Population in Saudi Arabia.Cureus · 2022Article
- Changes in Multimorbidity and Polypharmacy Patterns in Young and Adult Population over a 4-Year Period: A 2011-2015 Comparison Using Real-World Data.International journal of environmental research and public health · 2021Observational
- Epidemiological Study Assessing the Overuse of Proton Pump Inhibitors in Lebanese Population.Middle East journal of digestive diseases · 2020Article
- Use of Proton Pump Inhibitors in Hungary: Mixed-Method Study to Reveal Scale and Characteristics.Frontiers in pharmacology · 2020Article
- Using a Triple Aim Approach to Implement "Less-is-More Together" and Smarter Medicine Strategies in an Interprofessional Outpatient Setting: Protocol for an Observational Study.JMIR research protocols · 2019Article
- Improving prescribing for older patients - 'Yes S-I-R-E!'Singapore medical journal · 2019Observational
- Irrational use of proton pump inhibitors in general practise.Irish journal of medical science · 2019Article
- Prescription Pattern of Proton Pump Inhibitors at Hospital Admission and Discharge.GE Portuguese journal of gastroenterology · 2019Article
- When omeprazole met with asymptomatic Clostridium difficile colonization in a postoperative colon cancer patient: A case report.Medicine · 2017Article
- The use of proton pump inhibitors in an Italian hospital: focus on oncologic and critical non-ICU patients.International journal of clinical pharmacy · 2015Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere are growing concerns that the use of proton pump inhibitors (PPIs) may be inappropriate in instances that do not conform to evidence-based indications. This point-prevalence study aimed to investigate the frequency, indications and appropriateness of use of PPIs in hospitalised patients on a randomly chosen day.
methodsOn a randomly chosen day, all inpatients were documented, and those on any form of PPIs on that day were determined. Indications for maintaining these patients on PPIs were obtained from the electronic medical records, which were then recorded and cross-referenced against a list of accepted indications adapted from the US Food and Drug Administration (FDA)-approved list.
resultsIn all, 1,025 inpatients were documented. Of the 477 (46.5%) inpatients using PPIs, only 219 (45.9%) fulfilled the FDA-approved indications, while the majority (n = 258, 54.1%) did not. Overall, PPIs were not strictly indicated for use in 206 (43.2%) inpatients, according to FDA criteria. Of the 477 inpatients on PPIs, 52 (10.9%) had borderline indications based on expert consensus/guidelines other than FDA criteria.
conclusionAlthough the use of PPIs is prevalent in hospitals, less than half of the hospitalised patients using PPIs in our study had evidence-based indications that supported such use. The overuse of PPIs has a negative impact on healthcare costs and may lead to adverse effects. Steps to curb the inappropriate use of PPIs should address factors such as indications for the initiation of PPIs, and reassessment of the need for ongoing PPI use in inpatients upon discharge and during outpatient reviews.
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