Evidence map›Paper›PMID 25091868›Full record

ReviewNature reviews. Genetics2014

Recent advances in genomic DNA sequencing of microbial species from single cells.

Roger S Lasken, Jeffrey S McLean

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 156 citations in OpenAlex.

  1. Article
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  5. Liver abscess and septic shock due toFrontiers in medicine · 2025
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  20. Single-Cell Genomics and the Oral Microbiome.Journal of dental research · 2020
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Roger S LaskenJ. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, California 92037, USA.
Jeffrey S McLean1] J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, California 92037, USA. [2] School of Dentistry, Department of Periodontics, University of Washington, Seattle, Washington 98195, USA.
J. Craig Venter Institute · US

Funding

WHOLE GENOME AMPLIFICATION FOR RAPID LOW COST GENOTYPINGR01HG003647 · NHGRI · J. CRAIG VENTER INSTITUTE, INC. · PI LASKEN, ROGER SENDER · 2005 to 2013
$3.6M
Moving Beyond Diversity by Revealing Biological Functions of Uncultured BacteriaR01GM095373 · NIGMS · J. CRAIG VENTER INSTITUTE, INC. · PI MCLEAN, JEFFREY SCOTT, YOOSEPH, SHIBU · 2011 to 2014
$1.7M
NHGRI NIH HHS 2R01 HG003647NHGRI NIH HHS R01 HG003647NIAID NIH HHS HHSN272200900007CNIGMS NIH HHS 1R01GM095373NIGMS NIH HHS R01 GM095373
6 · The paper itself

Abstract

The vast majority of microbial species remain uncultivated and, until recently, about half of all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence. With the advent of single-cell sequencing, genomes of uncultivated species are rapidly filling in unsequenced branches of the microbial phylogenetic tree. The wealth of new insights gained from these previously inaccessible groups is providing a deeper understanding of their basic biology, taxonomy and evolution, as well as their diverse roles in environmental ecosystems and human health.

Indexed as

GenomicsMicrobiotaBacteriaDNA, BacterialDNA, RibosomalEvolution, MolecularGenetic VariationGenome, BacterialPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNADNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S

Identifiers

PMID25091868
PMCPMC4454502
OpenAlexW1964876346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.