ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2015
Does the use of neoadjuvant therapy for pancreatic adenocarcinoma increase postoperative morbidity and mortality rates?
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Smoking and Complications After Cancer Surgery: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer.The British journal of surgery · 2018Pooled it
- Article
- Impact of Neoadjuvant Treatment and Minimally Invasive Surgery on Perioperative Outcomes of Pancreatoduodenectomy: an ACS NSQIP Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Radiation therapy prior to a pancreaticoduodenectomy for adenocarcinoma is associated with longer operative times and higher blood loss.World journal of gastrointestinal surgery · 2023Article
- Neoadjuvant chemotherapy for borderline resectable and upfront resectable pancreatic cancer increasing overall survival and disease-free survival?Frontiers in oncology · 2022Article
- Optimal management of patients with operable pancreatic head cancer: A Markov decision analysis.Journal of surgical oncology · 2021Article
- Review
- Borderline resectable pancreatic cancer: Certainties and controversies.World journal of gastrointestinal surgery · 2021Review
- A Novel Pancreatic Fistula Risk Score Including Preoperative Radiation Therapy in Pancreatic Cancer Patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Analysis of the Curative Effect of Neoadjuvant Therapy on Pancreatic Cancer.Frontiers in oncology · 2021Review
- Survival Trends for Resectable Pancreatic Cancer Using a Multidisciplinary Conference: the Impact of Post-operative Chemotherapy.Journal of gastrointestinal cancer · 2020Article
- Association Between Pancreatic Fistula and Long-term Survival in the Era of Neoadjuvant Chemotherapy.JAMA surgery · 2019Article
- Efficacy and safety of preoperative 5-fluorouracil, cisplatin, and mitomycin C in combination with radiotherapy in patients with resectable and borderline resectable pancreatic cancer: a long-term follow-up study.World journal of surgical oncology · 2019Article
- Neoadjuvant therapy and pancreatic cancer: a national cancer database analysis.Journal of gastrointestinal oncology · 2019Article
- Article
- The issue of how predict survival of patients affected by locally advanced pancreatic cancer.Annals of translational medicine · 2018Article
- Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy.Journal of surgical oncology · 2018Article
- Neoadjuvant Radiation Is Associated with Fistula Formation Following Pancreaticoduodenectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles.BMC cancer · 2018Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
introductionThe impact of neoadjuvant therapy on postpancreatectomy complications is inadequately described.
methodsData from the NSQIP Pancreatectomy Demonstration Project (11/2011 to 12/2012) was used to identify patients with pancreatic adenocarcinoma who did and did not receive neoadjuvant therapy. Neoadjuvant therapy was classified as chemotherapy alone or radiation ± chemotherapy. Outcomes in the neoadjuvant vs. surgery first groups were compared.
resultsOf 1,562 patients identified at 43 hospitals, 199 (12.7%) received neoadjuvant therapy (99 chemotherapy alone and 100 radiation ± chemotherapy). Preoperative biliary stenting (57.9 vs. 44.7%, p = 0.0005), vascular resection (41.5 vs. 17.3%, p < 0.0001), and open resections (94.0 vs. 91.4%, p = 0.008) were more common in the neoadjuvant group. Thirty-day mortality (2.0 vs. 1.5%, p = 0.56) and postoperative morbidity rates (56.3 vs. 52.8%, p = 0.35) were similar between groups. Neoadjuvant therapy patients had fewer organ space infections (3.0 vs. 10.3%, p = 0.001), and neoadjuvant radiation patients had fewer pancreatic fistulas (7.3 vs. 15.4%, p = 0.03).
conclusionsDespite evidence for more extensive disease, patients receiving neoadjuvant therapy did not experience more complications. Neoadjuvant radiation was associated with lower pancreatic fistula rates. These data provide evidence against higher postoperative complication rates in patients with pancreatic cancer who are treated with neoadjuvant therapy.
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