ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2014
Clostridium difficile infection after colorectal surgery: a rare but costly complication.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Clostridium difficile infection after stoma reversal surgery: a systematic review and meta-analysis of the literature.International journal of colorectal disease · 2024Pooled it
- Cost of hospital management of Clostridium difficile infection in United States-a meta-analysis and modelling study.BMC infectious diseases · 2016Pooled it
- Association between postoperative Clostridioides difficile infection and outcomes following pancreatoduodenectomy for pancreatic cancer: a national cohort study.Surgical endoscopy · 2026Article
- Risk factors and outcomes of Clostridioides difficile infection in patients with colorectal cancer: critical perspective in management.Gut pathogens · 2025Review
- Predictors of Clostridium difficile infection after stoma reversal following TaTME surgery.Updates in surgery · 2023Article
- Effect of preoperative immunonutrition on fecal microbiota in colon cancer patients: a secondary analysis of a randomized controlled trial.Nutrition research and practice · 2023Article
- The Need of Antimicrobial Stewardship in Post-Operative Infectious Complications of Abdominal Surgery.Visceral medicine · 2022Review
- Article
- Analysis of Perioperative Risk Factors for Clostridium difficile Infection After a Colectomy.Cureus · 2021Article
- Effect of Inclusion of Oral Antibiotics with Mechanical Bowel Preparation on the Risk of Clostridium Difficile Infection After Colectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- The Impact of Opioid Epidemic Trends on Hospitalised Inflammatory Bowel Disease Patients.Journal of Crohn's & colitis · 2018Observational
- Characterizing Short-Term Outcomes Following Surgery for Rectal Cancer: the Role of Race and Insurance Status.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis.World journal of gastroenterology · 2016Review
- WSES guidelines for management of Clostridium difficile infection in surgical patients.World journal of emergency surgery : WJES · 2015Review
- Pre-operative granulocyte/lymphocyte ratio as a predictive marker of post-operative complications in patients with colorectal cancer.Oncology letters · 2015Article
- 2019 update of the WSES guidelines for management ofWorld journal of emergency surgery : WJESReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence and virulence of Clostridium difficile infection (CDI) are on the rise. The characteristics of patients who develop CDI following colorectal resection have been infrequently studied. MATERIALS AND
methodsWe utilized the University HealthSystem Consortium database to identify adult patients undergoing colorectal surgery between 2008 and 2012. We examined the patient-related risk factors for CDI and 30-day outcomes related to its occurrence.
resultsA total of 84,648 patients met our inclusion criteria, of which the average age was 60 years and 50% were female. CDI occurred in 1,266 (1.5%) patients during the years under study. The strongest predictors of CDI were emergent procedure, inflammatory bowel disease (IBD), and major/extreme APR-DRG severity of illness score. CDI was associated with a higher rate of complications, intensive care unit (ICU) admission, longer preoperative inpatient stay, 30-day readmission rate, and death within 30 days compared to non-CDI patients. Cost of the index stay was, on average, $14,130 higher for CDI patients compared with non-CDI patients.
conclusionEmergent procedures, higher severity of illness, and inflammatory bowel disease are significant risk factors for postoperative CDI in patients undergoing colorectal surgery. Once established, CDI is associated with worse outcomes and higher costs. The poor outcomes of these patients and increased costs highlight the importance of prevention strategies targeting high-risk patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.