ArticleIntensive care medicine2014
Effect of the use of low and high potency statins and sepsis outcomes.
Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of Statin Use on Sepsis Mortality: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Association of Preadmission Statin Use and Mortality in Critically Ill Patients: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies.Critical care (London, England) · 2016Pooled it
- Association Between Statin Use, Cytokine Storm, and Clinical Outcomes in COVID-19 Patients with Diabetes.Biomedicines · 2026Article
- Association between statin administration and outcome in patients with sepsis: A retrospective study.Open medicine (Warsaw, Poland) · 2025Article
- Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort.Journal of hepatology · 2022Article
- Statin Therapy for Hyperlipidemic Patients With Chronic Kidney Disease and End-Stage Renal Disease: A Retrospective Cohort Study Based on 925,418 Adults in Taiwan.Frontiers in pharmacology · 2022Article
- Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus.Cellular and molecular neurobiology · 2020Article
- Prior statin therapy and mortality among critically ill patients: a systemic review and meta-analysis of cohort studies.Annals of translational medicine · 2020Review
- Statins: a viable candidate for host-directed therapy against infectious diseases.Nature reviews. Immunology · 2019Review
- Statins influence epithelial expression of the anti-microbial peptide LL-37/hCAP-18 independently of the mevalonate pathway.Clinical and experimental immunology · 2019Article
- Effects of Statin Use in Advanced Chronic Kidney Disease Patients.Journal of clinical medicine · 2018Article
- Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice.Antimicrobial agents and chemotherapy · 2018Article
- Adjunctive therapies during veno-venous extracorporeal membrane oxygenation.Journal of thoracic disease · 2018Review
- Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection.Frontiers in immunology · 2018Article
- Statins in patients with sepsis and ARDS: is it over? We are not sure.Intensive care medicine · 2017Article
- Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia.Antimicrobial agents and chemotherapy · 2017Article
- The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study.Critical care (London, England) · 2017Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough statins have been shown to have cholesterol-lowering effects, their pleiotropic benefits on sepsis remain a matter of debate. In addition, the influence of statin potency on sepsis-related mortality has never been explored. The aim of our study was to determine the sepsis outcomes of low- and high-potency statin users and non-users.
methodsThis nationwide, population-based, propensity score-matched analysis used data from the linked administrative databases of Taiwan's National Health Insurance program. Patients were hospitalized for sepsis between 2000 and 2010. All-cause mortality and major adverse consequences of sepsis, such as in-hospital death, intensive care unit admission, shock events, and the use of mechanical ventilation, were assessed. Patients were divided into high-potency statin users (at least 10 mg rosuvastatin, at least 20 mg atorvastatin, or at least 40 mg simvastatin), low-potency statin users (all other statin treatments), and non-users.
resultsA propensity score-matched cohort of 27,792 statin users and 27,792 non-users was included. Of 27,792 statin users, 9,785 (35.2 %) were treated with high-potency statins and 18,007 (64.8 %) were treated with low-potency statins. The 1-year mortality risk was significantly lower among both low-potency [adjusted hazard ratio (aHR) 0.89, 95 % confidence interval (CI) 0.85-0.93] and high-potency (aHR 0.80, 95 % CI 0.75-0.86) statin users compared with non-users. The risks of mortality and adverse consequences of sepsis were lower among high-potency than among low-potency statin users.
conclusionsHigh-potency statin use is associated with a lower risk of sepsis-related mortality compared with low-potency statin use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.