ReviewNature reviews. Endocrinology2014
DSDs: genetics, underlying pathologies and psychosexual differentiation.
Review in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 157 citations in OpenAlex.
- Disorders of sex development: Genetic characterization of a patient cohort.Molecular medicine reports · 2020Trial
- Sex and Gender Differences in Physical Activity, Sedentary Behavior, and Sleep During Traumatic Brain Injury Recovery: A Narrative Review.European journal of sport science · 2026Review
- Sex/Gender Beliefs are Strongly Related to Either Right-Wing Authoritarian Conventionalism or Left-Wing Authoritarian Anti-Conventionalism.Archives of sexual behavior · 2026Article
- Documentation of biological sex and gender in missing person investigations.Forensic science international. Synergy · 2025Article
- Counting Sexes and Gender: Reflections on a Timeless Tension at the Heart of Psychology.Archives of sexual behavior · 2025Article
- Beyond Gender Binarism: Implications of Sex-Gender Diversity for Health Equity.Healthcare (Basel, Switzerland) · 2025Article
- Review
- 46,ΧΥ DSD in an adolescent with a novel de novo variant of the NR5A1 gene - case report and literature review.Hormones (Athens, Greece) · 2025Review
- Gene therapy for disorders of sex development: current applications and future challenges.Frontiers in genetics · 2025Review
- A case of complete androgen insensitivity syndrome combined with bilateral inguinal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Cytogenomic description of a Mexican cohort with differences in sex development.Molecular cytogenetics · 2024Article
- Identification and functional analysis of a rare variant of gene DHX37 in a patient with 46,XY disorders of sex development.Molecular genetics & genomic medicine · 2024Article
- Article
- Testicular differentiation in 46,XX DSD: an overview of genetic causes.Frontiers in endocrinology · 2024Review
- Diagnosis and management of non-CAH 46,XX disorders/differences in sex development.Frontiers in endocrinology · 2024Review
- Dermatologic care of patients with differences of sex development.International journal of women's dermatology · 2023Review
- The study of a hermaphroditic sheep caused by a mutation in the promoter ofVeterinary and animal science · 2023Article
- Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data.Life (Basel, Switzerland) · 2023Review
- Genetic control of typical and atypical sex development.Nature reviews. Urology · 2023Review
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mammalian sex determination is the unique process whereby a single organ, the bipotential gonad, undergoes a developmental switch that promotes its differentiation into either a testis or an ovary. Disruptions of this complex genetic process during human development can manifest as disorders of sex development (DSDs). Sex development can be divided into two distinct processes: sex determination, in which the bipotential gonads form either testes or ovaries, and sex differentiation, in which the fully formed testes or ovaries secrete local and hormonal factors to drive differentiation of internal and external genitals, as well as extragonadal tissues such as the brain. DSDs can arise from a number of genetic lesions, which manifest as a spectrum of gonadal (gonadal dysgenesis to ovotestis) and genital (mild hypospadias or clitoromegaly to ambiguous genitalia) phenotypes. The physical attributes and medical implications associated with DSDs confront families of affected newborns with decisions, such as gender of rearing or genital surgery, and additional concerns, such as uncertainty over the child's psychosexual development and personal wishes later in life. In this Review, we discuss the underlying genetics of human sex determination and focus on emerging data, genetic classification of DSDs and other considerations that surround gender development and identity in individuals with DSDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.