ArticleInternational journal of obesity (2005)2015
Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review).International journal of molecular medicine · 2026Review
- Article
- Efficacy of Human Recombinant Growth Hormone in Females of a Non-Obese Hyperglycemic Mouse Model after Birth with Low Birth Weight.International journal of molecular sciences · 2024Article
- The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways.Journal of cachexia, sarcopenia and muscle · 2024Review
- Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis.Redox biology · 2024Article
- Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans.Laboratory animal research · 2023Review
- Body Fat-Reducing Effects of Whey Protein Diet in Male Mice.Nutrients · 2023Article
- Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs.Veterinary sciences · 2023Article
- Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound.International journal of environmental research and public health · 2022Article
- Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.Experimental gerontology · 2022Article
- Adipose Dysfunction in Adulthood Insulin Resistance of Low-Birth Weight Mice: A Proteomics Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Fetal growth, high altitude, and evolutionary adaptation: a new perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Role of Cellular Stress in Intrauterine Growth Restriction and Postnatal Dysmetabolism.International journal of molecular sciences · 2021Review
- Article
- Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation.Emerging contaminants · 2021Article
- Association between birth weight and risk of overweight at adulthood in Labrador dogs.PloS one · 2020Article
- Low-Magnitude High-Frequency Vibration Decreases Body Weight Gain and Increases Muscle Strength by Enhancing the p38 and AMPK Pathways in db/db Mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Postnatal Nutrient Repartitioning due to Adaptive Developmental Programming.The Veterinary clinics of North America. Food animal practice · 2019Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIn utero undernutrition is associated with obesity and insulin resistance, although its effects on skeletal muscle remain poorly defined. Therefore, in the current study we explored the effects of in utero food restriction on muscle energy metabolism in mice.
methodsWe used an experimental mouse model system of maternal undernutrition during late pregnancy to examine offspring from undernourished dams (U) and control offspring from ad libitum-fed dams (C). Weight loss of 10-week-old offspring on a 4-week 40% calorie-restricted diet was also followed. Experimental approaches included bioenergetic analyses in isolated mitochondria, intact (permeabilized) muscle and at the whole body level.
resultsU have increased adiposity and decreased glucose tolerance compared to C. Strikingly, when U are put on a 40% calorie-restricted diet they lose half as much weight as calorie-restricted controls. Mitochondria from muscle overall from U had decreased coupled (state 3) and uncoupled (state 4) respiration and increased maximal respiration compared to C. Mitochondrial yield was lower in U than C. In permeabilized fiber preparations from mixed fiber-type muscle, U had decreased mitochondrial content and decreased adenylate-free leak respiration, fatty acid oxidative capacity and state 3 respiratory capacity through complex I. Fiber maximal oxidative phosphorylation capacity did not differ between U and C but was decreased with calorie restriction.
conclusionsOur results reveal that in utero undernutrition alters metabolic physiology through a profound effect on skeletal muscle energetics and blunts response to a hypocaloric diet in adulthood. We propose that mitochondrial dysfunction links undernutrition in utero with metabolic disease in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.