ArticleInternational wound journal2016
Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Aterofisiol(®) in carotid plaque evolution.Drug design, development and therapy · 2015Trial
- Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets.International journal of biological sciences · 2022Article
- Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia.International journal of molecular sciences · 2020Review
- PredyCLU: a prediction system for chronic leg ulcers based on fuzzy logic; part I - exploring the venous side.International wound journal · 2016Article
- The use of growth factors, CD34(+) cells and fibrin for the management of chronic venous ulcers.International wound journal · 2016Article
- Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study.International wound journal · 2016Article
- Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia.International wound journal · 2016Article
- Development, Optimization, and Characterization of PEGylated Nanoemulsion of Prostaglandin E1 for Long Circulation.AAPS PharmSciTech · 2016Article
- Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.Advances in nutrition (Bethesda, Md.) · 2015Review
- Various Types of Wounds That Diabetic Patients Can Develop: A Narrative Review.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed arterial and venous ulcers of the lower limbs are present in around 15-30% of patients with chronic venous ulcers (CVUs) and are considered difficult-to-heal wounds. The aim of this study was to evaluate the results of the treatment of mixed arterial and venous ulcers of the lower limbs with prostaglandin E1 (PGE1) infusion. This study was carried out in 48 consecutive patients. Patients who showed intolerability to PGE1, and patients with peripheral neuropathy, blood or systemic diseases, malignancy and acute wound infections or necrotic tissue on the wound bed were excluded. The patients were separated at random into two main groups: group I (25 patients) received standard treatment and PGE1 infusion. Group II (23 patients) received only standard treatment. Pre-treatment data indicated the area of ulceration. The number of healed ulcers and the variation in the area of ulceration were considered as endpoints. The endpoints were noticed after 120 days from the beginning of treatment. Healing occurred in 80% of limbs of group I and in 52·2% of limbs of group II patients. The average reduction in area was 92% versus 60% in patients of group I and II, respectively. During the whole treatment period, the incidence of adverse events was 8% in group I: there was one case of headache and one case of headache and hypotension combined. No side effects were recorded in patients of group II. In conclusion, PGE1 infusion is a determinant in the reduction of the healing time of mixed ulcers of the lower limbs.
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