ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Association between alcohol use disorder and the incidence of delirium in the intensive care unit: a retrospective cohort study using propensity score matching.BMC psychiatry · 2024Article
- Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.Addiction biology · 2024Article
- Executive and memory dysfunction related to binge drinking in stroke survivors during a 9-year follow-up.Frontiers in aging neuroscience · 2024Article
- The neuroimmune system - Where aging and excess alcohol intersect.Alcohol (Fayetteville, N.Y.) · 2023Review
- miR-96-5p is involved in alcohol-induced apoptosis in PC12 cells via negatively regulating TAp73.PloS one · 2023Article
- History of drinking problems diminishes the protective effects of within-guideline drinking on 18-year risk of dementia and CIND.BMC public health · 2021Article
- Elevated alcohol consumption among geriatric psychiatric in-patients.Nordisk alkohol- & narkotikatidskrift : NAT · 2020Article
- Demographic and Lifestyle Factors and Memory in European Older People.International journal of environmental research and public health · 2019Article
- Problematic drinking in the old and its association with muscle mass and muscle function in type II diabetes.Scientific reports · 2019Article
- Evolution of Dementia Related to the Use of Alcohol in the French Nationwide Discharge Summary Database Between 2007 and 2017.American journal of Alzheimer's disease and other dementias · 2019Article
- Making DEEP Sense of Lifestyle Risk and Resilience.Frontiers in aging neuroscience · 2019Article
- Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.International review of neurobiology · 2019Review
- Alcohol use and personality change in middle and older adulthood: Findings from the Health and Retirement Study.Journal of personality · 2018Article
- Effects of drinking on late-life brain and cognition.Evidence-based mental health · 2018Review
- Alcohol and prescribed psychotropic drug use among patients admitted to a department of old-age psychiatry in Norway.Nordisk alkohol- & narkotikatidskrift : NAT · 2017Article
- Association between alcohol drinking behaviour and cognitive function: results from a nationwide longitudinal study of South Korea.BMJ open · 2016Article
- Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.Experimental neurology · 2016Article
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.American journal of neurodegenerative disease · 2016Review
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease.American journal of neurodegenerative disease · 2016Review
- Matching Diabetes and Alcoholism: Oxidative Stress, Inflammation, and Neurogenesis Are Commonly Involved.Mediators of inflammation · 2015Review
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Abstract
objectiveTo assess the effects of a history of alcohol use disorders (AUDs) on risk of severe cognitive and memory impairment in later life.
methodsWe studied the association between history of AUDs and the onset of severe cognitive and memory impairment in 6,542 middle-aged adults born 1931 through 1941 who participated in the Health and Retirement Study, a prospective nationally representative U.S. cohort. Participants were assessed at 1992 baseline and follow-up cognitive assessments were conducted biannually from 1996 through 2010. History of AUDs was identified using the three-item modified CAGE questionnaire. Cognitive outcomes were assessed using the 35-item modified Telephone Interview for Cognitive Status at last follow-up with incident severe cognitive impairment defined as a score ≤ 8, and incident severe memory impairment defined as a score ≤ 1 on a 20-item memory subscale.
resultsDuring up to 19 years of follow-up (mean: 16.7 years, standard deviation: 3.0, range: 3.5-19.1 years), 90 participants experienced severe cognitive impairment and 74 participants experienced severe memory impairment. History of AUDs more than doubled the odds of severe memory impairment (odds ratio [OR] = 2.21, 95% confidence interval [CI] = 1.27-3.85, t = 2.88, df = 52, p = 0.01). The association with severe cognitive impairment was statistically non-significant but in the same direction (OR = 1.80, 95% CI = 0.97-3.33, t = 1.92, df = 52, p = 0.06).
conclusionMiddle-aged adults with a history of AUDs have increased odds of developing severe memory impairment later in life. These results reinforce the need to consider the relationship between alcohol consumption and cognition from a multifactorial lifespan perspective.
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