ArticleVision research2014
Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1.
Article in Vision research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Spontaneous Achromatopsia-Like Phenotype in Albino Swiss CD-1 Mice: Retinocortical Dysfunction, Neurovascular Remodeling, and Glial Activation.Investigative ophthalmology & visual science · 2026Article
- Exploring the Therapeutic Potential of Plant-Based Natural Products in Combating Aging.Current drug targets · 2026Review
- From Soma to Synapse: Imaging Age-Related Rod Photoreceptor Changes in the Mouse with Visible Light OCT.Ophthalmology science · 2023Article
- Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system forBiomedical optics express · 2023Article
- Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degeneration.Journal of neuroinflammation · 2022Article
- The understudied links of the retromer complex to age-related pathways.GeroScience · 2022Article
- Tracking distinct microglia subpopulations with photoconvertible Dendra2 in vivo.Journal of neuroinflammation · 2021Article
- Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa.Scientific reports · 2020Article
- Microglia Activation and Inflammation During the Death of Mammalian Photoreceptors.Annual review of vision science · 2020Review
- Article
- In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing.Scientific reports · 2019Article
- Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacyBiomedical optics express · 2019Article
- Article
- Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications.BioMed research international · 2019Review
- Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.Journal of neuroinflammation · 2018Article
- Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2018Article
- Loss of cone function without degeneration in a novel Gnat2 knock-out mouse.Experimental eye research · 2018Article
- The Spectral-Domain Optical Coherence Tomography Findings Associated with the Morphological and Electrophysiological Changes in a Rat Model of Retinal Degeneration, Rhodopsin S334ter-4 Rats.BioMed research international · 2018Article
- Characterization of photoreceptor degeneration in the rhodopsin P23H transgenic rat line 2 using optical coherence tomography.PloS one · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Microglia dynamically prune synaptic contacts during development, and digest waste that accumulates in degeneration and aging. In many neurodegenerative diseases, microglial activation and phagocytosis gradually increase over months or years, with poorly defined initial triggering events. Here, we describe rapid retinal microglial activation in response to physiological light levels in a mouse model of photoreceptor degeneration that arises from defective rhodopsin deactivation and prolonged signaling. Activation, migration and proliferation of microglia proceeded along a well-defined time course apparent within 12 h of light onset. Retinal imaging in vivo with optical coherence tomography revealed dramatic increases in light-scattering from photoreceptors prior to the outer nuclear layer thinning classically used as a measure of retinal neurodegeneration. This model is valuable for mechanistic studies of microglial activation in a well-defined and optically accessible neural circuit, and for the development of novel methods for detecting early signs of pending neurodegeneration in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.