SynthesisScientific reports2014
The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis.
Synthesis in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis.Scientific reports · 2016Pooled it
- Pooled it
- Influence of Cytokine Genetic Polymorphisms inGut and liver · 2024Article
- [AF4/FMR2 and IL-10 gene single nucleotide polymorphisms are correlated with disease susceptibility and immune infiltration in ankylosing spondylitis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma.BMC medical genetics · 2020Article
- Association of IL10 gene promoter polymorphisms with risks of gastric cancer and atrophic gastritis.The Journal of international medical research · 2018Article
- Article
- Protective effects of Xinji'erkang on myocardial infarction induced cardiac injury in mice.BMC complementary and alternative medicine · 2017Article
- A polymorphism in the promoter region of PD-L1 serves as a binding-site for SP1 and is associated with PD-L1 overexpression and increased occurrence of gastric cancer.Cancer immunology, immunotherapy : CII · 2017Article
- Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma.International journal of medical sciences · 2015Article
- Role of IL-10 gene polymorphisms on the susceptibility for esophageal cancer and its association with environmental factors.International journal of clinical and experimental pathology · 2015Article
- Interleukin-10 promotor -592A/C polymorphism is associated with slow coronary flow in Han Chinese.International journal of clinical and experimental pathology · 2015Article
- Association of Interleukin-10 promotor polymorphisms with atrial fibrillation in Han Chinese.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The -1082A>G polymorphism is located in promoter region of interleukin-10 (IL-10) and it could affect the production of IL-10. Numerous studies have investigated the association between IL-10 -1082A>G and risk of digestive cancer. However, the conclusion is still inconsistent. Here, we have performed a meta-analysis and systematic review to determine the association between the IL-10 -1082A>G and susceptibility to digestive cancer. In this meta-analysis, we identified 40 eligible studies, involving 7195 patients of digestive cancer and 11755 controls. By pooling all eligible studies, we found the variant -1082G allele significantly increased risk of digestive cancer (G vs. A: OR = 1.181, 95% CI: 1.057-1.319). Further stratified analysis was performed to evaluate the influence of cancer types, ethnicities, study design, sample size and Hardy-Weinberg equilibrium. Stratified analysis suggested that, the -1082A>G polymorphism was only associated with increased risk for gastric cancer (G vs. A: OR = 1.281, 95% CI: 1.102-1.488) and in Asian population (G vs. A: OR = 1.399, 95% CI: 1.188-1.646). No significant publication bias was detected. Based on 40 studies and 18950 participants, we found the variant IL-10 -1082G allele significantly increased susceptibility to digestive cancer, especially for gastric cancer and in Asian population.
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