ArticleBMC plant biology2014
Induction of innate immune responses by flagellin from the intracellular bacterium, 'Candidatus Liberibacter solanacearum'.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Flagellin-derived peptide flg22 from non-pathogenic Pseudomonas fragi Sneb1990 triggers plant immunity and reduces Meloidogyne incognita infestation.BMC plant biology · 2026Article
- Review
- Bacterial vector-borne plant diseases: global issues caused by three-way interactions.Crop health · 2025Review
- FlgI Is a Sec-Dependent Effector ofPlants (Basel, Switzerland) · 2024Article
- Unraveling the dynamics of Xanthomonas' flagella: insights into host-pathogen interactions.PeerJ · 2024Review
- Duplicated Flagellins in Pseudomonas Divergently Contribute to Motility and Plant Immune Elicitation.Microbiology spectrum · 2023Article
- Tad pilus-mediated twitching motility is essential for DNA uptake and survival of Liberibacters.PloS one · 2021Article
- The Rice DNA-Binding Protein ZBED Controls Stress Regulators and Maintains Disease Resistance After a Mild Drought.Frontiers in plant science · 2020Article
- Global gene expression in two potato cultivars in response to 'Candidatus Liberibacter solanacearum' infection.BMC genomics · 2017Article
- Extracellular Alkalinization as a Defense Response in Potato Cells.Frontiers in plant science · 2017Article
- Genomic sequence of 'Candidatus Liberibacter solanacearum' haplotype C and its comparison with haplotype A and B genomes.PloS one · 2017Article
- Bacillus cereus AR156 Extracellular Polysaccharides Served as a Novel Micro-associated Molecular Pattern to Induced Systemic Immunity to Pst DC3000 in Arabidopsis.Frontiers in microbiology · 2016Article
- Characterization and Functional Analysis of Calmodulin and Calmodulin-Like Genes inFrontiers in plant science · 2016Article
- Interactions "Candidatus Liberibacter solanacearum"-Bactericera cockerelli: Haplotype Effect on Vector Fitness and Gene Expression Analyses.Frontiers in cellular and infection microbiology · 2016Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background'Candidatus Liberibacter solanacearum' (Lso) is a phloem-limited alphaproteobacterium associated with the devastating zebra chip disease of potato (Solanum tuberosum). Like other members of Liberibacter, Lso-ZC1 encodes a flagellin domain-containing protein (Fla Lso ) with a conserved 22 amino-acid peptide (flg22 Lso ). To understand the innate immune responses triggered by this unculturable intracellular bacterium, we studied the pathogen-associated molecular patterns (PAMPs) that triggered immunity in Nicotiana benthamiana, using the flg22 Lso peptide and the full length fla Lso gene.
resultsOur results showed that the expression of fla Lso via Agrobacterium-mediated transient expression induced a slow necrotic cell death in the inoculated leaves of N. benthamiana, which was coupled with a burst of reactive oxygen species (ROS) production. Moreover, the expression of several representative genes involved in innate immunity was transiently up-regulated by the flg22 Lso in N. benthamiana. The Fla Lso , however, induced stronger up-regulation of these representative genes compared to the flg22 Lso , especially that of flagellin receptor FLAGELLIN SENSING2 (FLS2) and respiratory burst oxidase (RbohB) in N. benthamiana. Although neither cell death nor ROS were induced by the synthetic flg22 Lso , a weak callose deposition was observed in infiltrated leaves of tobacco, tomato, and potato plants.
conclusionThe flagellin of Lso and its functional domain, flg22 Lso share characteristics of pathogen-associated molecular patterns, and trigger unique innate immune responses in N. benthamiana. Slow and weak activation of the innate immune response in host plants by the flagellin of Lso may reflect the nature of its intracellular life cycle. Our findings provide new insights into the role of the Lso flagellin in the development of potato zebra chip disease and potential application in breeding for resistance.
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