ArticleMolecular microbiology2014
Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Multi-Antigen Protein Vaccine Confers Protection in a Murine Model Against IntranasalVaccines · 2026Article
- The Major Outer Membrane Protein P5 Binds Vitronectin to Mediate Serum Resistance in Nontypeable Haemophilus influenzae.The Journal of infectious diseases · 2025Article
- CRISPRi-seq in Haemophilus influenzae reveals genome-wide and medium-specific growth determinants.PLoS pathogens · 2025Article
- Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance.PLoS pathogens · 2025Article
- Multi-Component Vaccine Candidates Against Non-TypeableVaccines · 2025Article
- SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis.Emerging microbes & infections · 2024Article
- The human factor H protein family - an update.Frontiers in immunology · 2024Review
- Bacterial Outer Membrane Vesicles: Role in Pathogenesis and Host-Cell Interactions.Antibiotics (Basel, Switzerland) · 2023Review
- Outer membrane protein OMP76 ofVirulence · 2023Article
- Microbial evasion of the complement system: a continuous and evolving story.Frontiers in immunology · 2023Review
- Non-typeableFrontiers in cellular and infection microbiology · 2023Article
- NontypeableJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
- Learning from -omics strategies applied to uncoverComputational and structural biotechnology journal · 2021Review
- Hijacking Factor H for Complement Immune Evasion.Frontiers in immunology · 2021Review
- Interactions Between PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Article
- Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands.Infection and immunity · 2020Article
- Non-TypeableInternational journal of molecular sciences · 2020Article
- Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of NontypeableInfection and immunity · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Non-typeable Haemophilus influenzae is an opportunistic pathogen of the human upper respiratory tract and is often found to cause inflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pulmonary disease. To persist in the inflammatory milieu during infection, non-typeable H. influenzae must resist the antimicrobial activity of the human complement system. Here, we used Tn-seq to identify genes important for resistance to complement-mediated killing. This screen identified outer membrane protein P5 in evasion of the alternative pathway of complement activation. Outer membrane protein P5 was shown to bind human complement regulatory protein factor H directly, thereby, preventing complement factor C3 deposition on the surface of the bacterium. Furthermore, we show that amino acid variation within surface-exposed regions within outer membrane P5 affected the level of factor H binding between individual strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.