ArticleJournal of medical virology2015
Human metapneumovirus prevalence and molecular epidemiology in respiratory outbreaks in Ontario, Canada.
Article in Journal of medical virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Human metapneumovirus: pathogenesis, epidemiology, diagnostic technologies, and potential intervention strategies.Virology journal · 2025Review
- Review
- Re-Emergence of HMPV in Gwangju, South Korea, after the COVID-19 Pandemic.Pathogens (Basel, Switzerland) · 2023Article
- Global Extension and Predominance of Human Metapneumovirus A2 Genotype with Partial G Gene Duplication.Viruses · 2022Article
- Molecular detection and genetic characterization of human metapneumovirus strains circulating in Islamabad, Pakistan.Scientific reports · 2022Article
- Epidemiology and genotypic diversity of human metapneumovirus in paediatric patients with acute respiratory infection in Beijing, China.Virology journal · 2021Article
- Recent Molecular Evolution of Human Metapneumovirus (HMPV): Subdivision of HMPV A2b Strains.Microorganisms · 2020Article
- The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults.Virology journal · 2018Article
- Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes.Scientific reports · 2016Article
- Influenza-like illness outbreaks in nursing homes in Corsica, France, 2014-2015: epidemiological and molecular characterization.SpringerPlus · 2016Article
- Genome-Wide Analysis of Human Metapneumovirus Evolution.PloS one · 2016Article
- Human Metapneumovirus Infection in Jordanian Children: Epidemiology and Risk Factors for Severe Disease.The Pediatric infectious disease journal · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human metapneumovirus (hMPV) has been identified previously as a cause of respiratory outbreaks in adults, including the elderly. The objective of this study was to document respiratory outbreaks that were caused by hMPV in Ontario, Canada and to identify the various circulating genotypes during April 2009-February 2012. The majority of the outbreaks that were part of this study were in adults (>65 years). Total nucleic acid extraction was done on 123 residual anonymized clinical specimens from 51 different respiratory outbreaks. Specimens were subjected to PCR amplification and Sanger sequencing targeting the F and G genes of hMPV. Phylogenetic analysis was performed to identify genotypes. HMPV accounted for 195 (8.5%) of 2,292 respiratory outbreaks. Genotype A2b was most prevalent, detected in 28 (54.9%) of 51 typed hMPV-positive outbreaks. The genotype A2b2 that was described recently was also identified. In earlier reports, subtype A1 was reported in Canada which was absent in the specimens typed in this study. This shift in genotype may be significant in terms of disease severity, and for any future vaccine considerations. Regular testing for hMPV should be done as part of outbreak investigation.
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