ArticleNature communications2014
O-GlcNAc-mediated interaction between VER2 and TaGRP2 elicits TaVRN1 mRNA accumulation during vernalization in winter wheat.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 139 citations in OpenAlex.
- Population-scale gene expression analysis reveals the contribution of expression diversity to the modern wheat improvement.Nature communications · 2025Article
- Overexpression of TaCR4-A positively regulates grain size in Triticum aestivum.BMC plant biology · 2025Article
- Genetic mapping and haplotype analysis identify novel candidate genes for high night temperature tolerance in winter wheat.The plant genome · 2025Article
- Phenotypic plasticity of flowering time and plant height related traits in wheat.BMC plant biology · 2025Article
- A tale of two sugars: O-GlcNAc and O-fucose orchestrate growth, development, and acclimation in plants.Trends in biochemical sciences · 2025Review
- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- Targets and mechanisms of epigenetic regulation in the temperate cereal vernalisation process.Frontiers in plant science · 2025Review
- The E3 ligase TaE3V-B1 ubiquitinates proteins encoded by the vernalization gene TaVRN1 and regulates developmental processes in wheat.Plant physiology · 2024Article
- Chromatin loops gather targets of upstream regulators together for efficient gene transcription regulation during vernalization in wheat.Genome biology · 2024Article
- Transcription factor VRT2 reinitiates vernalization when interrupted by warm temperatures in a temperate grass model.Plant physiology · 2024Article
- Article
- Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat.Science China. Life sciences · 2024Article
- Epigenomic identification of vernalization cis-regulatory elements in winter wheat.Genome biology · 2024Article
- The TaSOC1-TaVRN1 module integrates photoperiod and vernalization signals to regulate wheat flowering.Plant biotechnology journal · 2024Article
- O-glycosylation of the transcription factor SPATULA promotes style development in Arabidopsis.Nature plants · 2024Article
- Hexosamine biosynthesis and related pathways, protein N-glycosylation and O-GlcNAcylation: their interconnection and role in plants.Frontiers in plant science · 2024Review
- A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat.Nature plants · 2024Article
- Analysis of the Structural Organization and Expression of thePlants (Basel, Switzerland) · 2023Article
- The Glycine-Rich RNA-Binding Protein Is a Vital Post-Transcriptional Regulator in Crops.Plants (Basel, Switzerland) · 2023Review
- Genetic basis of geographical differentiation and breeding selection for wheat plant architecture traits.Genome biology · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2025-09-05Concerns/Issues about Data · Concerns/Issues about Image · Duplication of/in Image · Euphemisms for Duplication · Investigation by Journal/Publisher · Investigation by Third Party · Manipulation of Images · Objections by Author(s) · Unreliable Data · · See also: https://pubpeer.com/publications/5E2EBA47D894099C375A47A965C274
- Retracted
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vernalization, sensing of prolonged cold, is important for seasonal flowering in eudicots and monocots. While vernalization silences a repressor (FLC, MADS-box transcription factor) in eudicots, it induces an activator (TaVRN1, an AP1 clade MADS-box transcription factor) in monocots. The mechanism for TaVRN1 induction during vernalization is not well understood. Here we reveal a novel mechanism for controlling TaVRN1 mRNA accumulation in response to prolonged cold sensing in wheat. The carbohydrate-binding protein VER2, a jacalin lectin, promotes TaVRN1 upregulation by physically interacting with the RNA-binding protein TaGRP2. TaGRP2 binds to TaVRN1 pre-mRNA and inhibits TaVRN1 mRNA accumulation. The physical interaction between VER2 and TaGRP2 is controlled by TaGRP2 O-GlcNAc modification, which gradually increases during vernalization. The interaction between VER2 and O-GlcNAc-TaGRP2 reduces TaGRP2 protein accumulation in the nucleus and/or promotes TaGRP2 dissociation from TaVRN1, leading to TaVRN1 mRNA accumulation. Our data reveal a new mechanism for sensing prolonged cold in temperate cereals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.