ReviewJournal of the American Society of Nephrology : JASN2015
New insights on the risk for cardiovascular disease in African Americans: the role of added sugars.
Review in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Community-Based Culturally Tailored Education Programs for Black Communities with Cardiovascular Disease, Diabetes, Hypertension, and Stroke: Systematic Review Findings.Journal of racial and ethnic health disparities · 2023Pooled it
- Significantly greater triglyceridemia in Black African compared to White European men following high added fructose and glucose feeding: a randomized crossover trial.Lipids in health and disease · 2016Trial
- Structural Barriers to Healthy Food and High-Sugar Consumption in Black Young Adult Women: The Mediating Role of Internal Health Locus of Control.Journal of racial and ethnic health disparities · 2026Article
- Long-term outcomes of a Mediterranean diet with or without calorie restriction on cognition and cardiometabolic health: The building research in diet and cognition trial.Preventive medicine reports · 2025Article
- Short and Long term glycemic control among Type 2 DM patients in a resource-limited setting.African health sciences · 2025Article
- Trends in Sugar From Packaged Foods and Beverages Purchased by US Households Between 2002 and 2020.Journal of the Academy of Nutrition and Dietetics · 2024Article
- Integrating the Social Determinants of Health Into Prelicensure Nursing Pharmacology.The Journal of nursing education · 2023Article
- Effect of Mediterranean diet and Mediterranean diet plus calorie restriction on cognition, lifestyle, and cardiometabolic health: A randomized clinical trial.Preventive medicine reports · 2022Article
- Ethnic differences in ApoC-III concentration and the risk of cardiovascular disease: No evidence for the cardioprotective role of rare/loss of functionAmerican heart journal plus : cardiology research and practice · 2022Article
- Differential DNA Methylation and Cardiometabolic Risk in African American Mother-Adolescent Dyads.Biological research for nursing · 2022Article
- Major adverse cardiovascular events in survivors of immune-mediated thrombotic thrombocytopenic purpura.American journal of hematology · 2021Article
- Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life.American journal of physiology. Heart and circulatory physiology · 2021Article
- Article
- Food Access and Cardiovascular Outcomes in Metropolitan Atlanta Census Tracts With Residents at Low Risk and High Risk of Cardiovascular Disease: The Morehouse-Emory Cardiovascular Center for Health Equity Study.Preventing chronic disease · 2021Article
- Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study.Journal of the American Heart Association · 2021Article
- Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study.Journal of translational medicine · 2020Article
- The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States.Nutrients · 2019Review
- Racial Differences in Cardiovascular Biomarkers in the General Population.Journal of the American Heart Association · 2019Article
- Article
- Genome-wide association study of coronary artery calcification in asymptomatic Korean populations.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By reviewing the relationship between cardiovascular and renal diseases and the African-American population during the early 20th century, the historic and recent associations of African heritage with cardiovascular disease, and modern population genetics, it is possible to assemble strong hypotheses for the primary underlying mechanisms driving the increased frequency of disease in African Americans. Our studies suggest that underlying genetic mechanisms may be responsible for the increased frequency of high BP and kidney disease in African Americans, with particular emphasis on the role of APOL1 polymorphisms in causing kidney disease. In contrast, the Western diet, particularly the relatively high intake of fructose-containing sugars and sweetened beverages, appears to be the dominant force driving the increased risk of diabetes, obesity, and downstream complications. Given that intake of added sugars is a remediable risk factor, we recommend clinical trials to examine the reduction of sweetened beverages as a primary means for reducing cardiovascular risk in African Americans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.