ArticleThe Journal of steroid biochemistry and molecular biology2014
The vitamin D system is deregulated in pancreatic diseases.
Article in The Journal of steroid biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Vitamin D Protects Pancreatic Cancer (PC) Cells from Death and DNA Damage Induced by Oxidative Stress.Antioxidants (Basel, Switzerland) · 2025Article
- Comparison of the role of vitamin D in normal organs and those affected by COVID-19.International journal of medical sciences · 2025Review
- Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review.International journal of molecular sciences · 2024Review
- Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner.International journal of molecular sciences · 2024Article
- Review
- Impact of gut microbiome in the development and treatment of pancreatic cancer: Newer insights.World journal of gastroenterology · 2023Review
- Expression of vitamin D receptor, CYP24A1, and CYP27B1 in normal and inflamed canine pancreases.Frontiers in veterinary science · 2023Article
- Review
- Vitamin D receptor methylation attenuates the association between physical activity and type 2 diabetes mellitus: A case-control study.Journal of diabetes · 2022Article
- Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer.Cancers · 2021Review
- The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma.Translational cancer research · 2020Article
- Review
- The role of collagen in cancer: from bench to bedside.Journal of translational medicine · 2019Review
- Vitamin D deficiency predicts severe acute pancreatitis.United European gastroenterology journal · 2019Article
- The roles of UVB and vitamin D in reducing risk of cancer incidence and mortality: A review of the epidemiology, clinical trials, and mechanisms.Reviews in endocrine & metabolic disorders · 2017Review
- Possible role of vitamin D3 on the adipocyte/fibroblast trans-differentiation mediated by pancreas cancerCurrent health sciences journalArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The vitamin D system is deregulated during development and progression of several cancer types. Data on the expression of the vitamin D system in the diseased pancreas are missing. The aim of this study was to investigate the expression of the vitamin D receptor (VDR), 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1), and the calcium-sensing receptor (CaSR), a vitamin D target gene, in the different regions of the pancreas in patients with chronic pancreatitis (n=6) and pancreatic ductal adenocarcinomas (PDAC) (n=17). We analyzed the expression of these genes at mRNA and protein level with quantitative real-time RT-PCR and immunostaining. mRNA expression of CYP24A1 and VDR was significantly increased in tumors compared with the adjacent non-tumorous tissue (p<0.01), while CaSR mRNA expression decreased. Both the VDR and the CaSR protein were highly expressed in the endocrine compared with the exocrine pancreas. In CP the CYP24A1 expression was highest in the endocrine pancreas, while in PDACs in the transformed ducts. In the PDAC patients CYP24A1 expression in the islets was significantly lower than in CP patients. Our data suggest that during ductal adenocarcinoma development the vitamin D system in the pancreas becomes deregulated on two levels: in the islets CYP24A1 expression decreases weakening the negative feedback regulation of the vitamin D-dependent insulin synthesis/secretion. In the transformed ducts CYP24A1 expression increases, impairing the antiproliferative effect of vitamin D in these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.