SynthesisInternational journal of environmental research and public health2014
Effects of air pollution on the risk of congenital anomalies: a systematic review and meta-analysis.
Synthesis in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Exposure to drinking water pollutants and non-syndromic birth defects: a systematic review and meta-analysis synthesis.BMJ open · 2024Pooled it
- Structural congenital anomalies in resource limited setting, 2023: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of Korean medical science · 2021Pooled it
- Pooled it
- Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants.Frontiers in cardiovascular medicine · 2021Pooled it
- Effects of long-term exposure to air pollution on the incidence of type 2 diabetes mellitus: a meta-analysis of cohort studies.Environmental science and pollution research international · 2020Pooled it
- Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review.JBI database of systematic reviews and implementation reports · 2019Pooled it
- Exposure to Nitrogen Oxide in the First Trimester and Risk of Cardiovascular-Related Malformations: A Dose-Response Meta-Analysis of Observational Studies.BioMed research international · 2018Pooled it
- The association between ambient air pollution and selected adverse pregnancy outcomes in China: A systematic review.The Science of the total environment · 2017Pooled it
- Pooled it
- Maternal environmental exposure and early-life health risks: The modulating role of nutritional status-A scoping review.iScience · 2026Review
- Prevalence and trends of major congenital anomalies in Brazil: A study from 2011 to 2020.PloS one · 2025Article
- Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model.Frontiers in public health · 2025Article
- Climate change, air pollution and maternal and newborn health: An overview of reviews of health outcomes.Journal of global health · 2024Review
- A Retrospective Observational Study Using Administrative Databases to Assess the Risk of Spontaneous Abortions Related to Environmental and Socioeconomic Conditions.Life (Basel, Switzerland) · 2023Article
- The Relationship between Air Pollution and Infant Mortality Rate.Iranian journal of public health · 2023Article
- Prevalence and associated factors of structural congenital anomalies in resource limited setting, 2023: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PMEnvironmental science and pollution research international · 2022Article
- Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring.Environmental science and pollution research international · 2021Review
- Seasonality of Hypoplastic Left Heart Syndrome and Single Ventricle Heart in Poland in the Context of Air Pollution.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital anomalies are the main causes of preterm and neonatal mortality and morbidity. We investigated the association between congenital anomalies and mothers' exposure to air pollution during pregnancy by combining risk estimates for a variety of air pollutants (SO2, NO2, PM10, PM2.5, CO and O3) and anomaly defect outcomes. Seventeen articles were included in the systematic review and thirteen studies were taken into account in the meta-analysis. Combined estimated were calculated separately according to whether the exposure metric was continuous or categorical. Only one significant combination was; NO2 concentrations were significantly associated with coarctation of the aorta (OR = 1.20 per 10 ppb, 95% CI, (1.02, 1.41)). This finding could stem from strong heterogeneity in study designs. Improved exposure assessment methods, in particular more accurate spatial measurements or modeling, standardized definition of cases and of better control of confounders are highly recommended for future congenital anomalies research in this area.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.