Evidence map›Paper›PMID 25089702›Full record

ArticlePloS one2014

Right ventricular function quantification in Takotsubo cardiomyopathy using two-dimensional strain echocardiography.

Felix Heggemann, Karsten Hamm, Joachim Brade, Florian Streitner, Christina Doesch, Theano Papavassiliu, Martin Borggrefe, Dariusch Haghi

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Role of Imaging in Cardiomyopathies.Cardiac failure review · 2023
    Review
  2. Review
  3. Review
  4. Article
  5. Novel Imaging and Genetic Risk Markers in Takotsubo Syndrome.Frontiers in cardiovascular medicine · 2021
    Review
  6. Takotsubo syndrome: the broken-heart syndrome.The British journal of cardiology · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Felix HeggemannFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Karsten HammDepartment of Cardiology, Center of Cardiovascular Medicine, Bad Neustadt, Germany.
Joachim BradeDepartment of Biometrics and Statistics, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Florian StreitnerFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Christina DoeschFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Theano PapavassiliuFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Martin BorggrefeFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Dariusch HaghiFirst Medical Department, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
University Medical Centre Mannheim · DEHeidelberg University · DERhön-Klinikum · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study sought to characterize global and regional right ventricular (RV) myocardial function in patients with Takotsubo cardiomyopathy (TC) using 2D strain imaging.

methodsWe compared various parameters of RV and left ventricular (LV) systolic function between 2 groups of consecutive patients with TC at initial presentation and upon follow-up. Group 1 had RV involvement and group 2 did not have RV involvement.

resultsAt initial presentation, RV peak systolic longitudinal strain (RVPSS) and RV fractional area change (RVFAC) were significantly lower in group 1 (-13.2±8.6% vs. -21.8±5.4%, p = 0.001; 30.7±9.3% vs. 43.5±6.3%, p = 0.001) and improved significantly upon follow-up. Tricuspid annular plane systolic excursion (TAPSE) did not differ significantly at initial presentation between both groups (14.8±4.1 mm vs. 17.9±3.5 mm, p = 0.050). Differences in regional systolic RV strain were only observed in the mid and apical segments. LV ejection fraction (LVEF) and LV global strain were significantly lower in group 1 (36±8% vs. 46±10%, p = 0.006 and -5.5±4.8% vs. -10.2±6.2%, p = 0.040) at initial presentation. None of the parameters were significantly different between the 2 groups upon follow-up. A RVPSS cut-off value of >-19.1% had a sensitivity of 85% and a specificity of 71% to discriminate between the 2 groups.

conclusionIn TC, RVFAC, RVPSS, LVEF and LV global strain differed significantly between patients with and without RV dysfunction, whereas TAPSE did not. 2 D strain imaging was feasible for the assessment of RV dysfunction in TC and could discriminate between patients with and without RV involvement in a clinically meaningful way.

Indexed as

AgedEchocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansMaleSystoleTakotsubo CardiomyopathyVentricular Function, Right

Identifiers

PMID25089702
PMCPMC4121208
OpenAlexW1968330729

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.