ArticlePloS one2014
Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Cross-Generational Integration of Exercise and Nutritional Encoding in Offspring Adipose Genomics.International journal of molecular sciences · 2026Review
- Molecular mechanisms underlying fetal bovine serum-induced developmental delay in mouse embryos: a data-independent acquisition (DIA)-based proteomics study.Frontiers in molecular biosciences · 2026Article
- Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.Human reproduction (Oxford, England) · 2024Article
- Single-cell profiling of mouse and primate ovaries identifies high levels ofMolecular therapy. Nucleic acids · 2023Article
- Identification ofGenes · 2022Article
- SSRE: Cell Type Detection Based on Sparse Subspace Representation and Similarity Enhancement.Genomics, proteomics & bioinformatics · 2021Article
- RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization.BMC genomics · 2020Article
- Genetics and functions of the retinoic acid pathway, with special emphasis on the eye.Human genomics · 2019Review
- Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development.BioMed research international · 2018Article
- Mechanisms of gene regulation in human embryos and pluripotent stem cells.Development (Cambridge, England) · 2017Review
- Lung organoids: current uses and future promise.Development (Cambridge, England) · 2017Review
- The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes.Cell reports · 2016Article
- Expression profile analysis of head and neck squamous cell carcinomas using data from The Cancer Genome Atlas.Molecular medicine reports · 2016Article
- Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.Development (Cambridge, England) · 2015Article
- Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.Nature communications · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several large-scale studies have been conducted to identify gene expression patterns for the first five days of human development, and many functional studies utilize mouse as a model system. We have identified genes of possible importance for this time period by analyzing human microarray data and available data from online databases. We selected 70 candidate genes for human preimplantation development and investigated their expression in the early mouse development from oocyte to the 8-cell stage. Maternally loaded genes expectedly decreased in expression during development both in human and mouse. We discovered that 25 significantly upregulated genes after fertilization in human included 13 genes whose orthologs in mouse behaved differently and mimicked the expression profile of maternally expressed genes. Our findings highlight many significant differences in gene expression patterns during mouse and human preimplantation development. We also describe four cancer-testis antigen families that are also highly expressed in human embryos: PRAME, SSX, GAGE and MAGEA.
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