Evidence map›Paper›PMID 25089193›Full record

ArticleInternational journal of obesity supplements2012

B lymphocytes as emerging mediators of insulin resistance.

D A Winer, S Winer, L Shen, M H Y Chng, E G Engleman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity supplements, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

D A WinerDepartment of Pathology, University Health Network, University of Toronto , Toronto, Ontario, Canada ; Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network, University of Toronto , Toronto, Ontario, Canada.
S WinerDepartment of Pathology, University Health Network, University of Toronto , Toronto, Ontario, Canada ; Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network, University of Toronto , Toronto, Ontario, Canada.
L ShenDepartment of Pathology, Stanford University , Palo Alto, CA, USA.
M H Y ChngDepartment of Pathology, Stanford University , Palo Alto, CA, USA.
E G EnglemanDepartment of Pathology, Stanford University , Palo Alto, CA, USA.
Stanford University · USPalo Alto University · USUniversity Health Network · CAUniversity of Toronto · CA

Funding

Biology and Immunology of Pancreatic Cancer Stem Cells in a Novel Mouse ModelU01CA141468 · NCI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2009 to 2013
$2.4M
Lupus Glomenulonephritis and NK T cellsR01DK082537 · NIDDK · STANFORD UNIVERSITY · PI STROBER, SAMUEL · 2009 to 2013
$2.3M
NCI NIH HHS U01 CA141468NIDDK NIH HHS R01 DK082537
6 · The paper itself

Abstract

Obesity is associated with chronic inflammation of various tissues including visceral adipose tissue (VAT), which contributes to insulin resistance. T cells and macrophages infiltrate VAT in obesity and orchestrate this inflammation. Recently, we made the surprising discovery that B cells are important contributors to this process. Thus, some B cells and the antibodies they produce can promote VAT-associated and systemic inflammation, leading to insulin resistance. This report will focus on the properties of these B cells, and how they contribute to insulin resistance through T-cell modulation and production of pathogenic autoantibodies. Understanding the mechanisms by which B cells contribute to insulin resistance should lead to new antibody-based diagnostics and B-cell modulating therapeutics to manage this increasingly prevalent disease.

Indexed as

autoantibodiesB lymphocytesinflammationinsulin resistance

Identifiers

PMID25089193
PMCPMC4109086
OpenAlexW2017983668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.