Evidence map›Paper›PMID 25089171›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2011

Instrument-free nucleic acid amplification assays for global health settings.

Paul LaBarre, David Boyle, Kenneth Hawkins, Bernhard Weigl

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paul LaBarreDiagnostics Group, PATH; 2201 Westlake Avenue; Suite 200; Seattle, WA 98121.
David BoyleDiagnostics Group, PATH; 2201 Westlake Avenue; Suite 200; Seattle, WA 98121.
Kenneth HawkinsDiagnostics Group, PATH; 2201 Westlake Avenue; Suite 200; Seattle, WA 98121.
Bernhard WeiglDiagnostics Group, PATH; 2201 Westlake Avenue; Suite 200; Seattle, WA 98121.

Funding

CaO-heated DNA amplification obviates electricity requirement at point of careR01EB012641 · NIBIB · PATH · PI BURTON, ROBERT ANDREW · 2011 to 2013
$1.8M
NIBIB NIH HHS R01 EB012641
6 · The paper itself

Abstract

Many infectious diseases that affect global health are most accurately diagnosed through nucleic acid amplification and detection. However, existing nucleic acid amplification tests are too expensive and complex for most low-resource settings. The small numbers of centralized laboratories that exist in developing countries tend to be in urban areas and primarily cater to the affluent. In contrast, rural area health care facilities commonly have only basic equipment and health workers have limited training and little ability to maintain equipment and handle reagents.

Indexed as

infection detectionlaminar flowLow-resource settingsmolecular diagnosticsnon-instrumented diagnosticsnucleic acid amplificationpoint of care diagnosticssample preparation

Identifiers

PMID25089171
PMCPMC4116599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.