ArticleOxidative medicine and cellular longevity2014
The higher plasma malondialdehyde concentrations are determined by metabolic syndrome-related glucolipotoxicity.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06104800 (Effect of Weight Loss on Hepcidin Levels and Iron Status in Subjects With Obesity.), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Weight Loss on Hepcidin Levels and Iron Status in Subjects With Obesity.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial.BMC complementary and alternative medicine · 2018Trial
- Plasma Malondialdehyde Reference Interval and Its Associations with Lifestyle Risk Factors in Thai Undergraduate Students: A Single-Center Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Linking serum malondialdehyde with dyslipidemia in patients with metabolic syndrome.Bioinformation · 2025Article
- The Cumulative and Single Effect of 12 Aldehydes Concentrations on Cardiovascular Diseases: An Analysis Based on Bayesian Kernel Machine Regression and Weighted Logistic Regression.Reviews in cardiovascular medicine · 2024Article
- Diets, Lifestyles and Metabolic Risk Factors among Corporate Information Technology (IT) Employees in South India.Nutrients · 2023Article
- Relationship between lipid accumulation product and oxidative biomarkers by gender in adults from Yucatan, Mexico.Scientific reports · 2022Article
- Potentilla chinensis aqueous extract attenuates cyclophosphamide-induced hemorrhagic cystitis in rat model.Scientific reports · 2022Article
- Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers.Antioxidants (Basel, Switzerland) · 2022Article
- The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats.International journal of molecular sciences · 2021Article
- Evaluation of some biological parameters of gasoline station attendants in Damascus, Syria.Heliyon · 2021Article
- Aortic Pulse Wave Velocity, Ankle-Brachial Index, and Malondialdehyde in Older Adults with or without Metabolic Syndrome.Pulse (Basel, Switzerland) · 2020Article
- Lycopene Modulates Pathophysiological Processes of Non-Alcoholic Fatty Liver Disease in Obese Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome.Oxidative medicine and cellular longevity · 2019Article
- The relationship between plasma lipids, oxidant-antioxidant status, and glycated proteins in individuals at risk for atherosclerosis.Clinical interventions in aging · 2019Article
- Factors associated with glycemic status and ability to adapt to changing demands in people with and without type 2 diabetes mellitus: A cross-sectional study.SAGE open medicine · 2018Article
- Metabolic syndrome, endocrine disruptors and prostate cancer associations: biochemical and pathophysiological evidences.Oncotarget · 2017Review
- Predicting disease onset in clinically healthy people.Interdisciplinary toxicology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), γ-glutamyltransferase (γ-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and γ-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
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