Evidence map›Paper›PMID 25089011›Full record

ReviewTrends in biochemical sciences2014

The growth-defense pivot: crisis management in plants mediated by LRR-RK surface receptors.

Youssef Belkhadir, Li Yang, Jonathan Hetzel, Jeffery L Dangl, Joanne Chory

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Plant Biostimulants to Enhance Abiotic Stress Resilience in Crops.International journal of molecular sciences · 2025
    Review
  9. Stem cell quiescence and dormancy in plant meristems.Journal of experimental botany · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Youssef BelkhadirGregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Li YangDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jonathan HetzelPlant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Biology, University of California, San Diego, Gilman Drive, La Jolla, CA 92037, USA.
Jeffery L DanglDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Microbiology and Immunology, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dangl@email.unc.edu.
Joanne ChoryHoward Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: chory@salk.edu.

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
The intersection of development and innate immune system function in Arabidopsis.R01GM107444 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANGL, JEFFERY L. · 2013 to 2020
$2.1M
Molecular Mechanisms of Steroid Hormone Perception at the Cell SurfaceR01GM094428 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CHORY, JOANNE · 2011 to 2014
$1.4M
Howard Hughes Medical InstituteNIGMS NIH HHS 1 R01 GM107444NIGMS NIH HHS 5 R01GM94428NIGMS NIH HHS R01 GM094428NIGMS NIH HHS R01 GM107444NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

Plants must adapt to their environment and require mechanisms for sensing their surroundings and responding appropriately. An expanded family of more than 200 leucine-rich repeat (LRR) receptor kinases (LRR-RKs) transduces fluctuating and often contradictory signals from the environment into changes in nuclear gene expression. Two LRR-RKs, BRASSINOSTEROID INSENSITIVE 1 (BRI1), a steroid receptor, and FLAGELLIN SENSITIVE 2 (FLS2), an innate immune receptor that recognizes bacterial flagellin, act cooperatively to partition necessary growth-defense trade-offs. BRI1 and FLS2 share common signaling components and slightly different activation mechanisms. BRI1 and FLS2 are paradigms for understanding the signaling mechanisms of LRR-containing receptors in plants.

Indexed as

ArabidopsisArabidopsis ProteinsModels, MolecularPlant DevelopmentProtein KinasesProtein Serine-Threonine KinasesRepetitive Sequences, Amino AcidSignal TransductionArabidopsis ProteinsBRI1 protein, ArabidopsisFLS2 protein, ArabidopsisProtein KinasesProtein Serine-Threonine Kinasescell surface signalingcrosstalkinnate immunityLRR-RKsplant growthtrade-offs

Identifiers

PMID25089011
PMCPMC4177940

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.