ArticleTissue engineering. Part A2015
Development of novel three-dimensional printed scaffolds for osteochondral regeneration.
Article in Tissue engineering. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
- Design and Characterization of Biomimetic Hybrid Construct Based on Hyaluronic Acid and Alginate Bioink for Regeneration of Articular Cartilage.Pharmaceutics · 2024Article
- Additive Manufacturing of Biomaterials-Design Principles and Their Implementation.Materials (Basel, Switzerland) · 2022Review
- Bio-inspired zonal-structured matrices for bone-cartilage interface engineering.Biofabrication · 2022Article
- Can activated titanium interbody cages accelerate or enhance spinal fusion? a review of the literature and a design for clinical trials.Journal of materials science. Materials in medicine · 2021Review
- 3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior.Cancers · 2021Review
- Advances in 3D Printing for Tissue Engineering.Materials (Basel, Switzerland) · 2021Review
- Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization.Bioactive materials · 2021Article
- 3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.Journal of materials science. Materials in medicine · 2020Article
- A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds.Polymers · 2020Article
- Materials and technical innovations in 3D printing in biomedical applications.Journal of materials chemistry. B · 2020Review
- Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces.Biofabrication · 2020Article
- Biofabrication for osteochondral tissue regeneration: bioink printability requirements.Journal of materials science. Materials in medicine · 2019Review
- 3D Bone Biomimetic Scaffolds for Basic and Translational Studies with Mesenchymal Stem Cells.International journal of molecular sciences · 2018Review
- The Evolution of Polystyrene as a Cell Culture Material.Tissue engineering. Part B, Reviews · 2018Review
- [Preparation andZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Recent Advances in Biomaterials for 3D Printing and Tissue Engineering.Journal of functional biomaterials · 2018Review
- Biotherapeutic Effect of Gingival Stem Cells Conditioned Medium in Bone Tissue Restoration.International journal of molecular sciences · 2018Article
- 4D printing of polymeric materials for tissue and organ regeneration.Materials today (Kidlington, England) · 2017Article
- Fabrication of Trabecular Bone-Templated Tissue-Engineered Constructs by 3D Inkjet Printing.Advanced healthcare materials · 2017Article
- From intricate to integrated: Biofabrication of articulating joints.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
As modern medicine advances, various methodologies are being explored and developed in order to treat severe osteochondral defects in joints. However, it is still very challenging to cure the osteochondral defects due to their poor inherent regenerative capacity, complex stratified architecture, and disparate biomechanical properties. The objective of this study is to create novel three-dimensional (3D) printed osteochondral scaffolds with both excellent interfacial mechanical properties and biocompatibility for facilitating human bone marrow mesenchymal stem cell (MSC) growth and chondrogenic differentiation. For this purpose, we designed and 3D printed a series of innovative bi-phasic 3D models that mimic the osteochondral region of articulate joints. Our mechanical testing results showed that our bi-phasic scaffolds with key structures have enhanced mechanical characteristics in compression (a maximum Young's modulus of 31 MPa) and shear (a maximum fracture strength of 5768 N/mm(2)) when compared with homogenous designs. These results are also correlated with numerical simulation. In order to improve their biocompatibility, the scaffolds' surfaces were further modified with acetylated collagen (one of the main components in osteochondral extracellular matrix). MSC proliferation results demonstrated that incorporation of a collagen, along with biomimetically designed micro-features, can greatly enhance MSC growth after 5 days in vitro. Two weeks' chondrogenic differentiation results showed that our novel scaffolds (dubbed "key" scaffolds), both with and without surface collagen modification, displayed enhanced chondrogenesis (e.g., 130%, 114%, and 236% increases in glycosaminoglycan, type II collagen deposition, and total protein content on collagen-modified key scaffolds when compared with homogeneous controls).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.