SynthesisCancer causes & control : CCC2014
Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium.
Synthesis in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The Mutational Epidemiology of Childhood Cancer.Clinical chemistry · 2025Review
- Causes of Childhood Cancer: A Literature Review (2014-2021)-Part 3: Environmental and Occupational Factors.Cancers · 2025Review
- Review
- In Utero Origins of Acute Leukemia in Children.Biomedicines · 2024Review
- Glyphosate in house dust and risk of childhood acute lymphoblastic leukemia in California.Environment international · 2023Article
- Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review.Cancers · 2022Review
- Risk of selected childhood cancers and parental employment in painting and printing industries: A register-based case‒control study in Denmark 1968-2015.Scandinavian journal of work, environment & health · 2019Article
- Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Review
- The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers.Paediatric and perinatal epidemiology · 2018Article
- How does the social environment during life course embody in and influence the development of cancer?International journal of public health · 2018Review
- Observational
- Spatial clustering of childhood leukaemia with the integration of the Paediatric Environmental History.Environmental research · 2017Article
- Trends in childhood leukemia incidence over two decades from 1992 to 2013.International journal of cancer · 2017Article
- A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California.Environmental research · 2016Article
- Childhood Leukemia: A Preventable Disease.Pediatrics · 2016Article
- Opportunities During Early Life for Cancer Prevention: Highlights From a Series of Virtual Meetings With Experts.Pediatrics · 2016Article
- Childhood Leukemia and Primary Prevention.Current problems in pediatric and adolescent health care · 2016Article
- Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium.Cancer causes & control : CCC · 2015Article
Corrections and comments
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Authors and funding
23 authors at 19 institutions in 9 countries.
Funding
Abstract
purposeIt has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.
methodsWe obtained individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.
resultsUsing individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95% confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95% CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95% CI 0.65, 1.41) and 1.31 (95% CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.
conclusionsNull findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.