ArticleNeuron2014
Sensory integration in mouse insular cortex reflects GABA circuit maturation.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
181 citing papers in PubMed, 319 citations in OpenAlex.
- Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios.Translational psychiatry · 2020Trial
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- Prefrontal Neurons Projecting to the Dorsomedial Striatum and Insular Cortex Support Reward Learning.Neuroscience bulletin · 2026Article
- Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy.Molecular psychiatry · 2026Article
- Comparative study of ERP habituation to tones and fearful vocalizations in autism spectrum disorders: a translational biomarker for sensory hypersensitivity.Molecular psychiatry · 2026Article
- Postnatal Development of Pyramidal Neurons Excitability and Synaptic Inputs in Mouse Gustatory Cortical Circuits.eNeuro · 2026Article
- Beta power as a neural correlate of sensory features in autistic individuals.Journal of neurodevelopmental disorders · 2026Article
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- In utero exposure to anti-Caspr2 antibody disrupts parvalbumin interneuron function in the hippocampus.Brain, behavior, and immunity · 2026Article
- Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia.Molecular psychiatry · 2026Article
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Rubber tail illusion is not obvious in SH3 and multiple ankyrin repeat domains 3 (Oxford open neuroscience · 2026Article
- Review
- Early postnatal dysfunction of ACC PV interneurons in Shank3BMolecular psychiatry · 2025Article
- Postnatal development of pyramidal neurons excitability and synaptic inputs in mouse gustatory cortical circuits.bioRxiv : the preprint server for biology · 2025Article
- A Rapid Anterior Auditory Processing Stream through the Insulo-parietal Auditory Field in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- The mouse posterior insular cortex encodes expressive and receptive aspects of courtship vocalizations.Cell reports · 2025Article
- Melanin-concentrating hormone and orexin shape social affective behavior via action in the insular cortex of rat.Psychopharmacology · 2025Article
- Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons.Journal of hazardous materials · 2025Article
121 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened γ-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.