ArticleNMR in biomedicine2014
Characterization of trabecular bone density with ultra-short echo-time MRI at 1.5, 3.0 and 7.0 T--comparison with micro-computed tomography.
Article in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Comparison of Peripheral Imaging Technologies for Bone and Muscle Quantification: a Mixed Methods Clinical Review.Current osteoporosis reports · 2016Pooled it
- Assessing Alveolar Bone Volume Fraction in Dental Implantology Using 1.5 Tesla Magnetic Resonance Imaging: AnIEEE open journal of engineering in medicine and biology · 2026Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications.Magma (New York, N.Y.) · 2024Review
- Ultrashort Echo Time and Zero Echo Time MRI and Their Applications at High Magnetic Fields: A Literature Survey.Investigative magnetic resonance imaging · 2024Article
- Placental T2* as a measure of placental function across field strength from 0.55T to 3T.Scientific reports · 2024Article
- Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Zero-TE MRI: principles and applications in the head and neck.The British journal of radiology · 2022Review
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- MRI-based mechanical competence assessment of bone using micro finite element analysis (micro-FEA): Review.Magnetic resonance imaging · 2022Review
- Advancements in Osteoporosis Imaging, Screening, and Study of Disease Etiology.Current osteoporosis reports · 2021Review
- Vertebral bone marrow T2* mapping using chemical shift encoding-based water-fat separation in the quantitative analysis of lumbar osteoporosis and osteoporotic fractures.Quantitative imaging in medicine and surgery · 2021Article
- Trabecular bone imaging using a 3D adiabatic inversion recovery prepared ultrashort TE Cones sequence at 3T.Magnetic resonance in medicine · 2020Article
- An Update in Qualitative Imaging of Bone Using Ultrashort Echo Time Magnetic Resonance.Frontiers in endocrinology · 2020Review
- Quantitative Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Bone: An Update.Frontiers in endocrinology · 2020Review
- MRI-derived bone porosity index correlates to bone composition and mechanical stiffness.Bone reports · 2019Article
- Positive Effects of Qing'e Pill () on Trabecular Microarchitecture and its Mechanical Properties in Osteopenic Ovariectomised Mice.Chinese journal of integrative medicine · 2019Article
- Assessment of alveolar bone marrow fat content using 15 T MRI.Oral surgery, oral medicine, oral pathology and oral radiology · 2018Article
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Authors and funding
8 authors.
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Abstract
The goal of this study was to test the potential of ultra-short echo-time (UTE) MRI at 1.5, 3.0 and 7.0 T for depiction of trabecular bone structure (of the wrist bones), to evaluate whether T2* relaxation times of bone water and parametric maps of T2* of trabecular bone could be obtained at all three field strengths, and to compare the T2* relaxation times with structural parameters obtained from micro-computed tomography (micro-CT) as a reference standard. Ex vivo carpal bones of six wrists were excised en bloc and underwent MRI at 1.5, 3.0 and 7.0 T in a whole-body MR imager using the head coil. A three-dimensional radial fat-suppressed UTE sequence was applied with subsequent acquisitions, with six different echo times TE of 150, 300, 600, 1200, 3500 and 7000 µs. The T2* relaxation time and pixel-wise computed T2* parametric maps were compared with a micro-computed-tomography reference standard providing trabecular bone structural parameters including porosity (defined as the bone-free fraction within a region of interest), trabecular thickness, trabecular separation, trabecular number and fractal dimension (Dk). T2* relaxation curves and parametric maps could be computed from datasets acquired at all field strengths. Mean T2* relaxation times of trabecular bone were 4580 ± 1040 µs at 1.5 T, 2420 ± 560 µs at 3.0 T and 1220 ± 300 µs at 7.0 T, when averaged over all carpal bones. A positive correlation of T2* with trabecular bone porosity and trabecular separation, and a negative correlation of T2* relaxation time with trabecular thickness, trabecular number and fractal dimension, was detected (p < 0.01 for all field strengths and micro-CT parameters). We conclude that UTE MRI may be useful to characterize the structure of trabecular bone, comparable to micro-CT.
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