ArticleReproductive toxicology (Elmsford, N.Y.)2014
PVP formulated fullerene (C60) increases Rho-kinase dependent vascular tissue contractility in pregnant Sprague Dawley rats.
Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Reproductive Toxicity of Nanoparticles: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Hydrophilization and Functionalization of Fullerene CPolymers · 2024Article
- Oral administration of TiOParticle and fibre toxicology · 2022Article
- Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure.Cardiovascular toxicology · 2019Article
- Maternal titanium dioxide nanomaterial inhalation exposure compromises placental hemodynamics.Toxicology and applied pharmacology · 2019Article
- Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure.Frontiers in cardiovascular medicine · 2017Article
- Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury.Particle and fibre toxicology · 2016Article
- Gestational nanomaterial exposures: microvascular implications during pregnancy, fetal development and adulthood.The Journal of physiology · 2016Article
- Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Distribution and biomarker of carbon-14 labeled fullerene C60 ([(14) C(U)]C60 ) in pregnant and lactating rats and their offspring after maternal intravenous exposure.Journal of applied toxicology : JAT · 2015Article
- Distribution and biomarkers of carbon-14-labeled fullerene C60 ([(14) C(U)]C60 ) in female rats and mice for up to 30 days after intravenous exposure.Journal of applied toxicology : JAT · 2015Article
- Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver.Journal of nanomedicine & nanotechnology · 2015Article
- Uterine microvascular sensitivity to nanomaterial inhalation: An in vivo assessment.Toxicology and applied pharmacology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Pregnancy is a unique physiological state, in which C60 fullerene is reported to be distributed in both maternal and fetal tissues. Tissue distribution of C60 differs between pregnant and non-pregnant states, presumably due to functional changes in vasculature during pregnancy. We hypothesized that polyvinylpyrrolidone (PVP) formulated C60 (C60/PVP) increases vascular tissue contractility during pregnancy by increasing Rho-kinase activity. C60/PVP was administered intravenously to pregnant and non-pregnant female Sprague Dawley rats. Vascular responses were assessed using wire myography 24h post-exposure. Increased stress generation was observed in uterine artery, thoracic aorta and umbilical vein. Rho-Rho-kinase mediated force maintenance was increased in arterial segments from C60/PVP exposed pregnant rats when compared to PVP exposed rats. Our findings suggest that intravenous exposure to C60/PVP during pregnancy increases vascular tissue contractility of the uterine artery through elements of Rho-Rho-kinase signaling during late stages of pregnancy.
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