Evidence map›Paper›PMID 25088242›Full record

ArticleVision research2014

Vergence eye movements in patients with schizophrenia.

Mark S Bolding, Adrienne C Lahti, David White, Claire Moore, Demet Gurler, Timothy J Gawne, Paul D Gamlin

Abstract read
In one paragraph

Article in Vision research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. CIDER: Enabling Robustness-Power Tradeoffs on a Computational Eyeglass.Proceedings of the ... annual International Conference on Mobile Computing and Networking. International Conference on Mobile Computing and Networking · 2015
    Article
  9. Ophthalmology issues in schizophrenia.Current psychiatry reports · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark S BoldingDepartment of Radiology, University of Alabama at Birmingham, 619 19th Street South, GSB 315, Birmingham, AL 35294-0017, USA; Department of Vision Sciences, University of Alabama at Birmingham, 1530 3rd Avenue South, WORB 186, Birmingham, AL 35294-0017, USA.
Adrienne C LahtiDepartment of Psychiatry, University of Alabama at Birmingham, 1530 3rd Avenue South, SC 501, Birmingham, AL 35294-0017, USA.
David WhiteDepartment of Psychiatry, University of Alabama at Birmingham, 1530 3rd Avenue South, SC 501, Birmingham, AL 35294-0017, USA.
Claire MooreDepartment of Radiology, University of Alabama at Birmingham, 619 19th Street South, GSB 315, Birmingham, AL 35294-0017, USA.
Demet GurlerDepartment of Radiology, University of Alabama at Birmingham, 619 19th Street South, GSB 315, Birmingham, AL 35294-0017, USA.
Timothy J GawneDepartment of Vision Sciences, University of Alabama at Birmingham, 1530 3rd Avenue South, WORB 186, Birmingham, AL 35294-0017, USA.
Paul D GamlinDepartment of Ophthalmology, 1103 Shelby Building, 1825 University Blvd., University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: pgamlin@uab.edu.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
Motor unit diversity in horizontal eye movement controlR01EY022290 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMLIN, PAUL DOUGLAS · 2012 to 2016
$2.7M
Treatment response in schizophrenia: bridging imaging and postmortem studiesR01MH081014 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAHTI, ADRIENNE C · 2009 to 2013
$1.8M
Stereoscopic motion-in-depth perception: fMRI and neurophysiological studiesR21EY018369 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMLIN, PAUL DOUGLAS · 2009 to 2010
$680k
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY022290NEI NIH HHS R21 EY018369NIMH NIH HHS R01 MH081014
6 · The paper itself

Abstract

Previous studies have shown that smooth pursuit eye movements are impaired in patients with schizophrenia. However, under normal viewing conditions, targets move not only in the frontoparallel plane but also in depth, and tracking them requires both smooth pursuit and vergence eye movements. Although previous studies in humans and non-human primates suggest that these two eye movement subsystems are relatively independent of one another, to our knowledge, there have been no prior studies of vergence tracking behavior in patients with schizophrenia. Therefore, we have investigated these eye movements in patients with schizophrenia and in healthy controls. We found that patients with schizophrenia exhibited substantially lower gains compared to healthy controls during vergence tracking at all tested speeds (e.g. 0.25 Hz vergence tracking mean gain of 0.59 vs. 0.86). Further, consistent with previous reports, patients with schizophrenia exhibited significantly lower gains than healthy controls during smooth pursuit at higher target speeds (e.g. 0.5 Hz smooth pursuit mean gain of 0.64 vs. 0.73). In addition, there was a modest (r≈0.5), but significant, correlation between smooth pursuit and vergence tracking performance in patients with schizophrenia. Our observations clearly demonstrate substantial vergence tracking deficits in patients with schizophrenia. In these patients, deficits for smooth pursuit and vergence tracking are partially correlated suggesting overlap in the central control of smooth pursuit and vergence eye movements.

Indexed as

AdultCase-Control StudiesConvergence, OcularFemaleHumansMaleMiddle AgedMotion PerceptionPhotic StimulationPursuit, SmoothSchizophreniaConvergence insufficiencySchizophreniaSmooth pursuitVergence

Identifiers

PMID25088242
PMCPMC4180079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.