ArticleBMC complementary and alternative medicine2014
Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- [Recommendations of the German Society for Rheumatology committee for complementary treatment and nutrition on phytotherapy : Supplement on the use of selected phytotherapeutic agents and herbal preparations in rheumatology: extension to include 13 medicinal plants].Zeitschrift fur Rheumatologie · 2026Review
- Equisetum hyemale enhances local bone regeneration in murine maxillary defects: an in vivo study.Odontology · 2026Article
- Protective Effects ofToxics · 2025Article
- Molecular, Physiological, and Histopathological Insights into the Protective Role ofLife (Basel, Switzerland) · 2025Article
- Phytochemical Composition and Antioxidant Activity of aPlants (Basel, Switzerland) · 2025Article
- A Novel Formulation Based on Resveratrol and Water Extracts fromFoods (Basel, Switzerland) · 2025Article
- Preparation and Evaluation of the Effectiveness of an Anti-Wrinkle Cream Containing Equisetum arvense and Soybean Extracts.Journal of cosmetic dermatology · 2025Article
- From Stem to Spectrum: Phytochemical Characterization of FiveMolecules (Basel, Switzerland) · 2024Article
- Phytochemical Investigation ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Horsetail (Pharmaceuticals (Basel, Switzerland) · 2023Article
- Investigation of the Genotoxic, Antigenotoxic and Antioxidant Profile of Different Extracts fromAntioxidants (Basel, Switzerland) · 2022Article
- Article
- Physicochemical Characteristics of Chitosan-Based Hydrogels Modified withMaterials (Basel, Switzerland) · 2021Article
- Article
- Phytochemistry and Pharmacology of the GenusEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Immunosuppressive Activity ofFrontiers in pharmacology · 2020Article
- Effects of a nutritional supplement in dogs affected by osteoarthritis.Veterinary medicine and science · 2019Article
- Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy.ACS omega · 2019Article
- Phytomedicine in Joint Disorders.Nutrients · 2017Review
- The effect of equisetum arvense (horse tail) ointment on wound healing and pain intensity after episiotomy: a randomized placebo-controlled trial.Iranian Red Crescent medical journal · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Europe, extracts of Equisetum arvense (common horsetail) have a long tradition in the treatment of inflammatory disorders. To understand the molecular basis for its use, we investigated the immunomodulatory capacity of a standardized commercially available common horsetail extract on human primary lymphocyte function in vitro.
methodsThe standardized extract of Equisetum arvense was phytochemically characterized. Effects on proliferation, viability and activity of mitogen-activated human lymphocytes were assessed in comparison to cyclosporine A using annexin V/propidium iodide staining assays and flow cytometry-based surface receptor characterization, respectively. Intracellular levels of effector molecules (IL-2, IFN-γ and TNF-α) were analyzed with cytokine assays.
resultsT cell proliferation was inhibited dose dependently by the Equisetum extract without induction of apoptosis or necrosis. This effect was mediated through inhibition of lymphocyte activation, specifically by diminishing CD69 and IL-2 surface receptor expression and intracellular IL-2 production. Furthermore, treatment with Equisetum arvense inhibited effector functions, as indicated by reduced production of IFN-γ and TNF-α.
conclusionsThe data indicate that the used extract of Equisetum arvense interferes with the polyfunctionality of immunocompetent cells thereby providing an anti-inflammatory mode-of-action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.