ArticleActa pharmacologica Sinica2014
Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes.
Article in Acta pharmacologica Sinica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Fatty liver index (FLI): more than a marker of hepatic steatosis.Journal of physiology and biochemistry · 2024Pooled it
- Low vitamin D levels are linked with increased cardiovascular disease risk in young adults: a sub-study and secondary analyses from the ACTIBATE randomized controlled trial.Journal of endocrinological investigation · 2024Trial
- Effects of vitamin D status and supplementation on MASLD severity in individuals with overweight or obesity: a cross-sectional study and randomized controlled trial.Journal of endocrinological investigation · 2026Article
- Vitamin D Sufficiency Revisited: Evidence of a Dose-Response Effect for MASLD in Adults at Risk.Nutrients · 2026Article
- Association of 25-Hydroxyvitamin D With Metabolic Dysfunction-Associated Fatty Liver Disease: Results From NHANES 2017-2018.International journal of endocrinology · 2025Article
- Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model.Nutrients · 2023Article
- Association and interaction between vitamin D level and metabolic syndrome for non-alcoholic fatty liver disease.Journal of diabetes and metabolic disorders · 2021Article
- Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study.Nutrition journal · 2021Article
- Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?World journal of gastroenterology · 2020Review
- Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta-Analysis.Hepatology communications · 2020Article
- Serum 25-hydroxyvitamin-D and nonalcoholic fatty liver disease: Does race/ethnicity matter? Findings from the MESA cohort.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2020Article
- Article
- Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels.Acta pharmacologica Sinica · 2015Article
- Can skin exposure to sunlight prevent liver inflammation?Nutrients · 2015Review
- Association between vitamin D and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: results from a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Neck circumference as an independent indicator to non-alcoholic fatty liver disease in non-obese men.Nutrition & metabolism · 2015Article
- Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Nonmedicinal interventions in nonalcoholic fatty liver disease.Canadian journal of gastroenterology & hepatologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimConsidering the characterization of vitamin D deficiency as a risk factor of ectopic fat deposition, the association of serum 25-hydroxy vitamin D3 [25(OH)D3] levels with non-alcoholic fatty liver disease (NAFLD) was evaluated in Chinese men with normal body mass index (BMI) and enzyme markers of liver function.
methodsA total of 514 participants (22 to 79 years old) with normal BMI and liver enzymes were identified for analysis. Abdominal ultrasound was performed to diagnose NAFLD, and the fatty liver index (FLI) was calculated to quantify liver steatosis. Serum 25(OH)D3 levels were determined by an electrochemiluminescence immunoassay.
resultsAmong the entire study population, the mean levels of serum 25(OH)D3 were 15.32±5.77 ng/mL. However, when serum 25(OH)D3 levels were compared between non-NAFLD subjects (n=438) and NAFLD subjects (n=76), the latter showed significantly lower levels (15.65±5.89 ng/mL vs 13.46±4.65 ng/mL, P=0.002). In addition, serum 25(OH)D3 levels were found to be significantly correlated with FLI after adjustment for age and BMI (r=-0.108, P=0.014). Logistic regression showed that serum 25(OH)D3 levels were independently correlated with NAFLD (OR: 0.937, 95% CI: 0.884-0.993, P=0.028). Furthermore, stepwise regression analysis revealed that serum 25(OH)D3 levels were inversely associated with FLI (β=-0.055, P=0.040).
conclusionThe present study demonstrated that serum 25(OH)D3 levels were inversely associated with NAFLD, even in subjects with normal total body fat, suggesting a potential role of lower levels of vitamin D in the occurrence and development of NAFLD.
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