Evidence map›Paper›PMID 25087904›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2014

Importance of metastatic lymph node ratio in non-metastatic, lymph node-invaded colon cancer: a clinical trial.

Arda Isik, Kemal Peker, Deniz Firat, Bahri Yilmaz, Ilyas Sayar, Oguz Idiz, Coskun Cakir, Ismail Demiryilmaz, Ismayil Yilmaz

Abstract readClinical Trial
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Pooled it
  2. Knockdown of TCTN1 Strongly Decreases Growth of Human Colon Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Pooled it
  3. Pooled it
  4. Association Between BRCA Status and P53 Status in Breast Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Pooled it
  5. Sham Feeding with Chewing Gum in Early Stage of Acute Pancreatitis: A Randomized Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Trial
  6. Transvaginal Mesh and Transanal Resection to Treat Outlet Obstruction Constipation Caused by Rectocele.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Trial
  7. Effects of Fentanyl and Morphine on Shivering During Spinal Anesthesia in Patients Undergoing Endovenous Ablation of Varicose Veins.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Trial
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  20. Predictive Value of Clinicopathological Characteristics for Sentinel Lymph Node Metastasis in Early Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arda IsikDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Kemal PekerDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Deniz FiratDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Bahri YilmazDepartment of General Surgery, Duzce State Hospital, Duzce, Turkey.
Ilyas SayarDepartment of Pathology, Erzincan University, Erzincan, Turkey.
Oguz IdizDepartment of General Surgery, Yunak State Hospital, Konya, Turkey.
Coskun CakirDepartment of General Surgery, Avicenna Hospital, Istanbul, Turkey.
Ismail DemiryilmazDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Ismayil YilmazDepartment of General Surgery, Erzincan University, Erzincan, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the prognostic importance of the metastatic lymph node ratio for stage III colon cancer patients and to find a cut-off value at which the overall survival and disease-free survival change. MATERIAL/

methodsPatients with pathological stage III colon cancer were retrospectively evaluated for: age; preoperative values of Crp, Cea, Ca 19-9, and Afp; pathologic situation of vascular, perineural, lymphatic, and serosal involvement; and metastatic lymph node ratio values were calculated.

resultsThe study included 58 stage III colon cancer patients: 20 (34.5%) females and 38 (65.5%) males were involved in the study. Multivariate analysis was applied to the following variables to evaluate significance for overall survival and disease-free survival: age, Crp, Cea, perineural invasion, and metastatic lymph node ratio. The metastatic lymph node ratio (<0.25 or ≥0.25) is the only independent variable significant for overall and disease-free survival.

conclusionsMetastatic lymph node ratio is an ideal prognostic marker for stage III colon cancer patients, and 0.25 is the cut-off value for prognosis.

Indexed as

Biomarkers, TumorAge FactorsColonic NeoplasmsDisease-Free SurvivalFemaleHumansLymphatic MetastasisMaleMultivariate AnalysisNeoplasm InvasivenessPrognosisRetrospective StudiesBiomarkers, Tumor

Identifiers

PMID25087904
PMCPMC4136934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.