ArticleAnnals of neurology2014
Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years.
Article in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.Neurology · 2026Article
- Juvenile myoclonic epilepsy heterogeneity uncovered: Z-mapped imaging endophenotypes of cortical and subcortical structures and their clinical, cognitive and psychiatric features.Brain communications · 2026Article
- General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy.Epilepsia open · 2025Article
- Genetic Animal Models of Idiopathic Generalized Epilepsies: What Can We Learn from Them?Biomedicines · 2025Review
- Juvenile Myoclonic Epilepsy Imaging Endophenotypes and Relationship With Cognition and Resting-State EEG.Human brain mapping · 2025Article
- Latent cognitive phenotypes in juvenile myoclonic epilepsy: Clinical, sociodemographic, and neuroimaging associations.Epilepsia · 2025Article
- The co-activation patterns of multiple brain regions in Juvenile Myoclonic Epilepsy.Cognitive neurodynamics · 2024Review
- Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review.Pediatric reports · 2023Article
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- Cognitive phenotype of juvenile absence epilepsy: An investigation of patients and unaffected siblings.Epilepsia · 2023Article
- Digital Neuropsychological Assessment of Cognitive Functions in Patients with Epilepsy.Noro psikiyatri arsivi · 2023Article
- Article
- Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives.Frontiers in molecular neuroscience · 2022Review
- Neuroimaging in the Epileptic Baboon.Frontiers in veterinary science · 2022Review
- Genetically proxied gut microbiota, gut metabolites with risk of epilepsy and the subtypes: A bi-directional Mendelian randomization study.Frontiers in molecular neuroscience · 2022Article
- Brain functional and structural characteristics of patients with seizure recurrence following drug withdrawal.Neuroradiology · 2021Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- The Timing, Nature, and Range of Neurobehavioral Comorbidities in Juvenile Myoclonic Epilepsy.Pediatric neurology · 2019Article
- Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings.Neurology · 2019Article
- Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings.Brain : a journal of neurology · 2019Observational
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9 authors.
Funding
Abstract
objectiveAdults with juvenile myoclonic epilepsy (JME) have subtle brain structural abnormalities in the frontothalamocortical network, poorer cognitive function, and worse long-term social outcomes, even when their seizures are controlled and/or remitted. The natural history of JME and development of abnormalities in brain structure and cognition from epilepsy onset has not been studied.
methodsThe maturational trajectories of cognitive and brain development were prospectively compared between 19 children with new-onset JME in the first 2 years after diagnosis and 57 healthy controls.
resultsCognitive abilities of children with JME were similar to or worse than healthy controls at baseline but failed to reach the competence level of healthy controls at follow-up across most of the tested cognitive abilities. Abnormal patterns of brain development, as assessed by magnetic resonance imaging studies, were evident in children with JME and included attenuation of age-related decline in cortical volume, thickness, and surface area compared to typically developing children. The altered brain developmental trajectory in the JME group was evident in higher-association frontoparietotemporal brain regions (p < 0.05, corrected for multiple comparisons).
interpretationChildren with JME have abnormal structural brain development and impaired cognitive development early in the course of their epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.