ArticleRespiratory physiology & neurobiology2014
CO2-inhibited neurons in the medullary raphé are GABAergic.
Article in Respiratory physiology & neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Chloride Modulates Central pH Sensitivity and Plasticity of Brainstem Breathing-Related Biorhythms in Zebra Finch Embryos.Developmental psychobiology · 2024Article
- Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice.eLife · 2022Article
- Article
- Inhibitory mechanisms control active expiration by limiting parafacial expiratory drive.Journal of neurophysiology · 2021Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea.Journal of neurophysiology · 2015Article
- Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity.Journal of neurophysiology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Previous studies have reported subsets of medullary raphé neurons that are either stimulated or inhibited by CO2/pH in vitro, in situ, and in vivo. We tested the hypothesis that medullary raphé CO2-inhibited neurons are GABAergic. Extracellular recordings in unanesthetized juvenile in situ rat preparations showed reversible hypercapnia-induced suppression of 19% (63/323) of medullary raphé neurons, and this suppression persisted after antagonism of NMDA, AMPA/kainate, and GABAA receptors. We stained a subset of CO2-inhibited cells and found that most (11/12) had glutamic acid decarboxylase 67 immunoreactivity (GAD67-ir). These data indicate that the majority of acidosis-inhibited medullary raphé neurons are GABAergic, and that their chemosensitivity is independent of major fast synaptic inputs. Thus, CO2-sensitive GABAergic neurons may play a role in central CO2/pH chemoreception.
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