ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
Early detection of heterotopic ossification using near-infrared optical imaging reveals dynamic turnover and progression of mineralization following Achilles tenotomy and burn injury.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Impact of heterotopic ossification following lumbar total disk replacement: a systematic review.BMC musculoskeletal disorders · 2022Pooled it
- Early detection of aberrant cell fate and repair using circulating progenitor cells in patients with heterotopic ossification.Nature communications · 2026Article
- A rare mass with atypical localization: Heterotopic ossification associated with flexor hallucis longus.Joint diseases and related surgery · 2024Article
- High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents.Stem cells and development · 2021Article
- Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging.Bioengineering & translational medicine · 2021Article
- Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights.Frontiers in bioengineering and biotechnology · 2021Review
- Heterotopic Ossification: A Comprehensive Review.JBMR plus · 2019Review
- Review
- Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.Nature biomedical engineering · 2017Article
- Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- The traumatic bone: trauma-induced heterotopic ossification.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System.Annals of surgery · 2017Article
- Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.Annals of surgery · 2016Article
- Direct Mouse Trauma/Burn Model of Heterotopic Ossification.Journal of visualized experiments : JoVE · 2015Article
- Heterotopic Ossification: Basic-Science Principles and Clinical Correlates.The Journal of bone and joint surgery. American volume · 2015Review
- The development and impact of heterotopic ossification in burns: a review of four decades of research.Scars, burns & healingReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Heterotopic ossification (HO) is the abnormal formation of bone in soft tissue. Current diagnostics have low sensitivity or specificity to incremental progression of mineralization, especially at early time points. Without accurate and reliable early diagnosis and intervention, HO progression often results in incapacitating conditions of limited range of motion, nerve entrapment, and pain. We hypothesized that non-invasive near-infrared (NIR) optical imaging can detect HO at early time points and monitor heterotopic bone turnover longitudinally. C57BL6 mice received an Achilles tenotomy on their left hind limb in combination with a dorsal burn or sham procedure. A calcium-chelating tetracycline derivative (IRDye 680RD BoneTag) was injected bi-weekly and imaged via NIR to measure accumulative fluorescence for 11 wk and compared to in vivo microCT images. Percent retention of fluorescence was calculated longitudinally to assess temporal bone resorption. NIR detected HO as early as five days and revealed a temporal response in HO formation and turnover. MicroCT could not detect HO until 5 wk. Confocal microscopy confirmed fluorophore localization to areas of HO. These findings demonstrate the ability of a near-infrared optical imaging strategy to accurately and reliably detect and monitor HO in a murine model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.